Screening of pharmaceuticals and illicit drugs in wastewater and surface waters of Spain and Italy by high resolution mass spectrometry using UHPLC-QTOF MS and LC-LTQ-Orbitrap MS
Screening of pharmaceuticals and illicit drugs in wastewater and surface waters of Spain and Italy by high resolution mass spectrometry using UHPLC-QTOF MS and LC-LTQ-Orbitrap MS
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DOI：
10.1007/s00216-015-9063-x
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发表时间：
2015-12-01
影响因子：
4.3
通讯作者：
Hernandez, Felix
中科院分区：
文献类型：
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作者：
Bade, Richard;Rousis, Nikolaos I.;Hernandez, Felix
环境沃茨中药物和违禁药物的存在促使许多分析化学家开发了用于监测目的的筛选方法。水样可能含有大量可能的污染物，通常浓度较低，这使得它们的检测和识别成为问题。液相色谱-高分辨质谱联用技术（LC-HRMS）已被证明是筛选环境污染物的有效方法。目前的工作调查使用最流行的高分辨质谱仪器，四极飞行时间和线性陷阱四极轨道阱，从两个不同的实验室。对来自西班牙东部Castelln和北方意大利Cremona的废水（流入物和流出物）和地表水样品进行了可疑PID筛选，纳入了107个PID（包括220个碎片离子）的数据库。两种仪器和样本的调查结果进行了比较，突出了在每种情况下应用的策略的优点和缺点。总之，通过任一/两种仪器检测和/或鉴定了28种化合物，其中厄贝沙坦、缬沙坦、苯甲酰芽子碱和咖啡因是所有样品中最常见的化合物。
The existence of pharmaceuticals and illicit drugs (PIDs) in environmental waters has led many analytical chemists to develop screening methods for monitoring purposes. Water samples can contain a huge number of possible contaminants, commonly at low concentrations, which makes their detection and identification problematic. Liquid chromatography coupled with high resolution mass spectrometry (LC-HRMS) has proven itself effective in the screening of environmental contaminants. The present work investigates the use of the most popular HRMS instruments, quadrupole time-of-flight and linear trap quadrupole-Orbitrap, from two different laboratories. A suspect screening for PIDs was carried out on wastewater (influent and effluent) and surface water samples from Castelln, Eastern Spain, and Cremona, Northern Italy, incorporating a database of 107 PIDs (including 220 fragment ions). A comparison between the findings of both instruments and of the samples was made which highlights the advantages and drawbacks of the strategies applied in each case. In total, 28 compounds were detected and/or identified by either/both instruments with irbesartan, valsartan, benzoylecgonine and caffeine being the most commonly found compounds across all samples.