Susceptibility of human enterotoxigenic Escherichia coli isolates to growth inhibition by porcine intestinal epithelial cells
Susceptibility of human enterotoxigenic Escherichia coli isolates to growth inhibition by porcine intestinal epithelial cells
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DOI：
10.1111/j.1574-6968.2007.00814.x
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发表时间：
2007-09-01
影响因子：
2.1
通讯作者：
Hardwidge, Philip R.
中科院分区：
文献类型：
--
作者：
Brown, Eric A.;Kaushik, Radhey S.;Hardwidge, Philip R.
人而不是猪肠毒素大肠杆菌分离株在与猪肠道上皮细胞孵育过程中受到抑制，并受到未刺激细胞上清液中存在的结构性产生因子(S)的抑制。抑制因子(S)是热稳定性的，不是由血清饥饿的细胞产生的，存在于各种动物的培养上皮细胞系中，但不是人类来源的。对猪肠道上皮细胞的敏感性似乎仅限于ETEC，而不是E.ColiO157：H7疾病分离株。
Growth of human, but not porcine enterotoxigenic Escherichia coli (ETEC) isolates is inhibited during incubation with porcine intestinal epithelial cells and by a constitutively produced factor(s) present in unstimulated cell supernatants. The inhibitory factor(s) is heat stable, not produced by serum-starved cells, and is present in a diverse number of cultured epithelial cell lines of animal, but not of human origin. Susceptibility to porcine intestinal epithelial cells appears to be restricted to ETEC and not E. coli O157:H7 disease isolates.