Serum betaine is inversely associated with low lean mass mainly in men in a Chinese middle-aged and elderly community-dwelling population
Serum betaine is inversely associated with low lean mass mainly in men in a Chinese middle-aged and elderly community-dwelling population
复制标题
血清甜菜碱与低瘦体重呈负相关，主要发生在中国中老年社区居住人群的男性中
DOI：
10.1017/s0007114516001380
复制
发表时间：
2016-06-28
影响因子：
3.6
通讯作者：
Zhu, Hui-lian
中科院分区：
文献类型：
--
作者：
Huang, Bi-xia;Zhu, Ying-ying;Zhu, Hui-lian
以前的研究表明，甜菜碱补充剂增加牲畜的瘦体重，改善人类的肌肉性能，但其对人类瘦体重影响的证据有限。我们的研究评估了中国成年人循环甜菜碱与瘦体重及其组成的关系。2008 - 2010年对1996名广州市50-75岁居民（体重/体质量：1381/615）进行了基于社区的研究。使用访谈者管理的问卷来收集一般基线信息。使用HPLC-MS评估空腹血清甜菜碱。在平均3.2年的随访期间，共有1590名参与者完成了使用双能X射线吸收法进行的身体成分分析。经年龄校正后，回归分析显示，血清甜菜碱与男性全身、躯干和四肢的瘦体重百分比（LM%）（均P < 0.05）和女性躯干的LM%（P = 0.016）呈正相关。血清甜菜碱的每个SD增加与LM%增加相关，男性为0.609（全身）、0.811（躯干）、0.422（四肢）、0.632（手臂）和0.346（腿部），女性为0.350（躯干）。多元Logistic回归分析显示，血清甜菜碱每增加一个SD，女性LM%降低17%（全身）和14%（躯干），男性LM %降低23%（全身）、28%（躯干）、22%（手臂）和26%（骨骼肌指数百分比）。在中国中老年人中，尤其是男性，循环甜菜碱水平升高与LM%升高和LM%降低的患病率降低相关。
Previous studies have demonstrated that betaine supplements increase lean body mass in livestock and improve muscle performance in human beings, but evidence for its effect on human lean mass is limited. Our study assessed the association of circulating betaine with lean mass and its composition in Chinese adults. A community-based study was conducted on 1996 Guangzhou residents (weight/mass: 1381/615) aged 50-75 years between 2008 and 2010. An interviewer-administered questionnaire was used to collect general baseline information. Fasting serum betaine was assessed using HPLC-MS. A total of 1590 participants completed the body composition analysis performed using dual-energy X-ray absorptiometry during a mean of 3.2 years of follow-up. After adjustment for age, regression analyses demonstrated a positive association of serum betaine with percentage of lean mass (LM%) of the entire body, trunk and limbs in men (all P < 0.05) and LM% of the trunk in women (P = 0.016). Each SD increase in serum betaine was associated with increases in LM% of 0.609 (whole body), 0.811 (trunk), 0.422 (limbs), 0.632 (arms) and 0.346 (legs) in men and 0.350 (trunk) in women. Multiple logistic regression analysis revealed that the prevalence of lower LM% decreased by 17% (whole body) and 14% (trunk) in women and 23% (whole body), 28% (trunk), 22% (arms) and 26% (percentage skeletal muscle index) in men with each SD increment in serum betaine. Elevated circulating betaine was associated with a higher LM% and lower prevalence of lower LM% in middle-aged and elderly Chinese adults, particularly men.