Primate rhinal cortex participates in both visual recognition and working memory tasks: Functional mapping with 2-DG
Primate rhinal cortex participates in both visual recognition and working memory tasks: Functional mapping with 2-DG
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DOI：
10.1152/jn.2001.85.6.2590
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发表时间：
2001-06-01
影响因子：
2.5
通讯作者：
Goldman-Rakic, PS
中科院分区：
文献类型：
--
作者：
Davachi, L;Goldman-Rakic, PS
内侧颞叶的鼻皮层与物体识别记忆任务有关，并且确实被认为是视觉记忆网络中的关键节点。先前使用2-脱氧葡萄糖方法的研究表明，在非人类灵长类动物中，被认为参与视觉识别记忆的丘脑和海马结构也参与空间和物体工作记忆任务。参与记忆处理的网络可以通过分析伴随特定设计任务的激活模式来识别。在本研究中，我们比较了三种工作记忆任务（延迟反应（DR）、延迟交替（DA）和延迟对象交替（DOA））与标准识别记忆任务（延迟匹配样本（DMS））和感觉运动控制任务在恒河猴工作记忆任务中诱导的内嗅皮层和周围皮层代谢激活。一项兴趣区分析显示，在执行DA、DOA和DMS任务的动物中，局部脑葡萄糖利用在嗅周皮层升高，而执行DMS任务的动物在侧边嗅周皮质中表现出强烈的激活焦点。在执行记忆和控制任务的组之间，内嗅皮层没有明显的差异。这些发现表明，周围皮层在记忆处理中可能扮演的角色比之前认为的要广泛得多，包括外显工作记忆和识别记忆。
The rhinal cortex in the medial temporal lobe has been implicated in object recognition memory tasks and indeed is considered to be the critical node in a visual memory network. Previous studies using the 2-deoxyglucose method have shown that thalamic and hippocampal structures thought to be involved in visual recognition memory are also engaged by spatial and object working memory tasks in the nonhuman primate. Networks engaged in memory processing can be recognized by analysis of patterns of activation accompanying performance of specifically designed tasks. In the present study, we compared metabolic activation of the entorhinal and perirhinal cortex during the performance of three working memory tasks [delayed response (DR), delayed alternation (DA), and delayed object alternation (DOA)] to that induced by a standard recognition memory task [delayed match-to-sample (DMS)] and a sensorimotor control task in rhesus monkeys. A region-of-interest analysis revealed elevated local cerebral glucose utilization in the perirhinal cortex in animals performing the DA, DOA, and DMS tasks, and animals performing the DMS task were distinct in showing a strong focus of activation in the lateral perirhinal cortex. No significant differences were evident between groups performing memory and control tasks in the entorhinal cortex. These findings suggest that the perirhinal cortex may play a much broader role in memory processing than has been previously thought, encompassing explicit working memory as well as recognition memory.