Helminthic infection down-regulates type 1 immune responses in human T cell lymphotropic virus type 1 (HTLV-1) carriers and is more prevalent in HTLV-1 carriers than in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis.
Helminthic infection down-regulates type 1 immune responses in human T cell lymphotropic virus type 1 (HTLV-1) carriers and is more prevalent in HTLV-1 carriers than in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis.
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DOI：
10.1086/427560
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发表时间：
2005-02
期刊：
影响因子：
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通讯作者：
A. Porto;S. Santos;A. Muniz;Vanessa Basilio;W. Rodrigues;F. Neva;W. Dutra;K. Gollob;S. Jacobson;E. Carvalho
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文献类型：
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作者：
A. Porto;S. Santos;A. Muniz;Vanessa Basilio;W. Rodrigues;F. Neva;W. Dutra;K. Gollob;S. Jacobson;E. Carvalho
人类T细胞嗜淋巴细胞病毒1型（HTLV-1）感染与1型免疫应答加剧和高水平促炎细胞因子分泌有关。相反，蠕虫感染诱导2型免疫应答。在本研究中，将与蠕虫（粪类圆线虫和/或曼氏血吸虫）共感染的HTLV-1携带者的细胞因子谱与未与蠕虫共感染的HTLV-1携带者的细胞因子谱进行了比较。未合并感染蠕虫的HTLV-1携带者的干扰素（IFN）-γ水平高于合并感染蠕虫的HTLV-1携带者（P<0.05）。在HTLV-1携带者与蠕虫共感染中，表达IFN-γ的CD 8+和CD 4+细胞的总体频率降低（P<0.05）。同时感染蠕虫的HTLV-1携带者表达IL-5和IL-10的T细胞百分比高于未感染蠕虫的HTLV-1携带者（P<0.05）。此外，我们发现HTLV-1携带者的蠕虫感染率是HTLV-1相关性脊髓病/热带痉挛性下肢轻瘫患者的7倍（P<0.05）。这些数据表明，蠕虫感染降低了1型细胞的活化，这可能会影响HTLV-1感染的临床结果。
Human T cell lymphotropic virus type 1 (HTLV-1) infection is associated with an exacerbated type 1 immune response and secretion of high levels of proinflammatory cytokines. In contrast, helminthic infection induces a type 2 immune response. In the present study, the cytokine profile in HTLV-1 carriers coinfected with helminths (Strongyloides stercoralis and/or Schistosoma mansoni) was compared with that in HTLV-1 carriers not coinfected with helminths. Levels of interferon (IFN)- gamma were higher in HTLV-1 carriers not coinfected with helminths than in HTLV-1 carriers coinfected with helminths (P<.05). The overall frequency of IFN- gamma -expressing CD8+ and CD4+ cells was decreased in HTLV-1 carriers coinfected with helminths (P<.05). The percentage of interleukin (IL)-5- and IL-10-expressing T cells in HTLV-1 carriers coinfected with helminths was higher than that in HTLV-1 carriers not coinfected with helminths (P<.05). Moreover, we found that the prevalence of helminthic infection was 7-fold higher in HTLV-1 carriers than in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (P<.05). These data show that helminthic infection decreases activation of type 1 cells, which may influence the clinical outcome of HTLV-1 infection.