Radon, Smoking and Lung Cancer Risk: Results of a Joint Analysis of Three European Case-Control Studies Among Uranium Miners
Radon, Smoking and Lung Cancer Risk: Results of a Joint Analysis of Three European Case-Control Studies Among Uranium Miners
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DOI：
10.1667/rr2377.1
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发表时间：
2011-09-01
影响因子：
3.4
通讯作者：
Laurier, Dominique
中科院分区：
文献类型：
--
作者：
Leuraud, Klervi;Schnelzer, Maria;Laurier, Dominique
对嵌套在三个欧洲铀矿工人队列中的三个病例对照研究进行了联合分析，以研究氡暴露和吸烟对肺癌死亡风险的联合影响。职业史和接触数据可从队列中获得。使用自填式问卷和职业医学档案重建吸烟信息。线性超额相对风险模型调整吸烟被用来估计肺癌的风险与氡暴露。该研究包括1046例肺癌病例和2492例对照，并提供了详细的氡暴露数据和吸烟状况。经吸烟校正的ERR/WLM等于0.008（95% CI：0.004-0.014）。暴露后的时间被证明是氡暴露与肺癌风险之间关系的主要修正因素。拟合几何混合模型产生的参数赞成氡和吸烟之间的子乘法相互作用。这项联合研究是调查氡和吸烟对矿工肺癌风险的联合影响的最大病例对照研究。结果证实，即使在调整吸烟因素后，氡的肺癌效应仍然存在，支持氡和吸烟之间的亚倍增相互作用的论点。(C)2011年，辐射研究学会
A combined analysis of three case-control studies nested in three European uranium miner cohorts was performed to study the joint effects of radon exposure and smoking on lung cancer death risk. Occupational history and exposure data were available from the cohorts. Smoking information was reconstructed using self-administered questionnaires and occupational medical archives. Linear excess relative risk models adjusted for smoking were used to estimate the lung cancer risk associated with radon exposure. The study includes 1046 lung cancer cases and 2492 controls with detailed radon exposure data and smoking status. The ERR/WLM adjusted for smoking is equal to 0.008 (95% CI: 0.004-0.014). Time since exposure is shown to be a major modifier of the relationship between radon exposure and lung cancer risk. Fitting geometric mixture models yielded arguments in favor of a sub-multiplicative interaction between radon and smoking. This combined study is the largest case-control study to investigate the joint effects of radon and smoking on lung cancer risk among miners. The results confirm that the lung carcinogenic effect of radon persists even when smoking is adjusted for, with arguments in favor of a sub-multiplicative interaction between radon and smoking. (C) 2011 by Radiation Research Society