Long-term brain impairment in chronic alcoholics: N2-P3 cognitive potentials in a template-matching memory task.
Long-term brain impairment in chronic alcoholics: N2-P3 cognitive potentials in a template-matching memory task.
复制标题
慢性酗酒者的长期脑损伤：模板匹配记忆任务中的 N2-P3 认知潜力。
DOI：
10.1093/oxfordjournals.alcalc.a044563
复制
发表时间：
1985
影响因子：
2.8
通讯作者：
D. Schopflocher
中科院分区：
文献类型：
--
作者：
K. Ciesielski;J. Madden;J. Bligh;D. Schopflocher
从看似完整的慢性酗酒者和正常对照中收集了由模板匹配视觉记忆任务引起的神经心理学测量和 N2-P3 视觉认知电位。酗酒者和对照组之间的心理测量结果没有显着差异，但酗酒者的 N2-P3 认知电位显示出幅度下降和非典型的半球间潜伏期模式，表明与酒精相关的缺陷。 N2 和 P3 的不同功能性质以及可能独立的颅内起源表明这些缺陷分别位于皮质和海马。认知脑电位是比心理测量数据更敏感的脑损伤指标。
Neuropsychological measurements and N2-P3 visual cognitive potentials evoked by a template-matching visual-memory task were collected from seemingly intact chronic alcoholics and normal controls. Psychometric results were not significantly different between alcoholics and controls, but the N2-P3 cognitive potentials of the alcoholic population showed a decreased amplitude and an atypical interhemispheric pattern of latencies that point to alcohol-related deficits. The different functional nature and possibly separate intracranial origin of N2 and P3 suggest respective cortical and hippocampal localisation of these deficits. Cognitive brain potentials were a more sensitive indicator of cerebral impairment than psychometric data.