Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways.
Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways.
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DOI：
10.1186/2049-3002-2-3
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发表时间：
2014-02-04
影响因子：
5.9
通讯作者：
Ratcliffe PJ
中科院分区：
文献类型：
--
作者：
Masson N;Ratcliffe PJ
肿瘤缺氧和代谢失调是癌症的典型特征。最近的分析揭示了致癌激活、缺氧信号系统和癌症中失调的代谢途径之间复杂的相互关系。这些研究表明，代谢和缺氧信号通路不仅对能量耗尽或肿瘤缺氧引起的错误信号作出反应，而且在许多点上与致癌信号机制直接相关。本文将总结目前的理解缺氧诱导因子（HIF）在这些网络中的作用。它还将讨论这些相互关联的途径在产生癌症表型中的作用;特别是，切换生理上“硬连线”的致癌机制驱动癌症的大规模途径的影响。
Both tumor hypoxia and dysregulated metabolism are classical features of cancer. Recent analyses have revealed complex interconnections between oncogenic activation, hypoxia signaling systems and metabolic pathways that are dysregulated in cancer. These studies have demonstrated that rather than responding simply to error signals arising from energy depletion or tumor hypoxia, metabolic and hypoxia signaling pathways are also directly connected to oncogenic signaling mechanisms at many points. This review will summarize current understanding of the role of hypoxia inducible factor (HIF) in these networks. It will also discuss the role of these interconnected pathways in generating the cancer phenotype; in particular, the implications of switching massive pathways that are physiologically 'hard-wired’ to oncogenic mechanisms driving cancer.