A Fast-Slow Analysis of the Dynamics of REM Sleep
A Fast-Slow Analysis of the Dynamics of REM Sleep
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DOI：
10.1137/110832823
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发表时间：
2012-01-01
影响因子：
2.1
通讯作者：
Booth, Victoria
中科院分区：
文献类型：
--
作者：
Behn, Cecilia G. Diniz;Booth, Victoria
觉醒和睡眠状态由脑干和下丘脑中的许多神经元群体的协调活动调节，其突触相互作用构成睡眠-觉醒调节网络。睡眠-觉醒调节网络的基于生理学的数学模型包含在多个时间尺度上操作的机制，包括神经元群体之间相对快速的基于突触的相互作用，以及调节睡眠-觉醒时间模式的慢得多的稳态和昼夜节律过程。在这项研究中，我们利用自然产生的缓慢的时间尺度的稳态睡眠驱动减少睡眠-觉醒调节网络模型，利用快-慢分析，调查的动态快速眼动（REM）睡眠调节。该网络模型由数量减少的觉醒、非快速眼动（NREM）睡眠和快速眼动睡眠促进神经元群组成，其突触相互作用反映了睡眠-觉醒调节的相互抑制触发概念模型和REM睡眠调节的相互作用模型。网络动态在清醒和睡眠状态之间定期交替，这是由缓慢的稳态睡眠驱动所控制的。通过改变与REM-促进群体的激活相关的参数，我们导致睡眠发作期间的REM动力学从抑制到单次激活再到规则的REM-NREM循环，对应于由昼夜节律调节诱导的REM模式的变化，并在不同的哺乳动物物种中观察到。我们还利用快-慢分析来解释复杂的影响，在模拟实验中，不同的神经递质的激动剂和拮抗剂被微量注射到特定的神经元群体参与睡眠-觉醒调节网络的睡眠-觉醒模式。
Waking and sleep states are regulated by the coordinated activity of a number of neuronal populations in the brainstem and hypothalamus whose synaptic interactions compose a sleep-wake regulatory network. Physiologically based mathematical models of the sleep-wake regulatory network contain mechanisms operating on multiple time scales including relatively fast synaptic-based interactions between neuronal populations, and much slower homeostatic and circadian processes that modulate sleep-wake temporal patterning. In this study, we exploit the naturally arising slow time scale of the homeostatic sleep drive in a reduced sleep-wake regulatory network model to utilize fast-slow analysis to investigate the dynamics of rapid eye movement (REM) sleep regulation. The network model consists of a reduced number of wake-, non-REM (NREM) sleep-, and REM sleep-promoting neuronal populations with synaptic interactions reflecting the mutually inhibitory flip-flop conceptual model for sleep-wake regulation and the reciprocal interaction model for REM sleep regulation. Network dynamics regularly alternate between wake and sleep states as governed by the slow homeostatic sleep drive. By varying a parameter associated with the activation of the REM-promoting population, we cause REM dynamics during sleep episodes to vary from suppression to single activations to regular REM-NREM cycling, corresponding to changes in REM patterning induced by circadian modulation and observed in different mammalian species. We also utilize fast-slow analysis to explain complex effects on sleep-wake patterning of simulated experiments in which agonists and antagonists of different neurotransmitters are microinjected into specific neuronal populations participating in the sleep-wake regulatory network.