Mild behavioral impairment and risk of dementia: a prospective cohort study of 358 patients.
Mild behavioral impairment and risk of dementia: a prospective cohort study of 358 patients.
复制标题
轻度行为障碍和痴呆症风险：358例患者的前瞻性队列研究。
DOI：
10.4088/jcp.08m04181
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发表时间：
2009-04
期刊：
影响因子：
--
通讯作者：
Lyketsos CG
中科院分区：
文献类型：
--
作者：
Taragano FE;Allegri RF;Krupitzki H;Sarasola DR;Serrano CM;Loñ L;Lyketsos CG
轻度认知障碍(MCI)是一种介于正常衰老和痴呆症之间的过渡状态，至少对一些患者来说是这样。MCI患者的行为症状与较高的痴呆症风险相关，但它们与无MCI患者的痴呆症风险的相关性尚不清楚。轻度行为障碍(MBI)是指在没有明显认知症状的情况下，伴有明显的精神和相关行为症状的晚年综合征，也可能是痴呆的前驱症状。比较MCI和MBI患者，并估计这两组患者发生痴呆的风险。一组连续的358名患者(239名MCI患者和119名MBI患者)在门诊综合医院专科诊所接受了长达5年的跟踪调查，直到转化为痴呆症或进行审查。34%的轻度认知障碍患者和70%以上的脑梗塞患者发展为痴呆(logrank p=0.011)。没有认知症状的脑梗塞患者更有可能发展为痴呆症(logrank p<；0.001)。与阿尔茨海默病(AD)相比，MBI患者更有可能因额颞部退行性变(FTD)而患上痴呆症。MBI似乎是正常衰老和痴呆症之间的过渡状态。MBI(特别是那些没有认知症状的人)可能比MCI有更高的痴呆症风险，在许多情况下很可能是FTD的前驱症状。这些发现对于关注新的行为症状的出现，对老年痴呆患者的早期发现、预防和治疗具有重要意义。
Mild cognitive impairment (MCI) is a transitional state between normal ageing and dementia, at least for some patients. Behavioral symptoms in MCI are associated with a higher risk of dementia, but their association with dementia risk in patients without MCI is unknown. Mild Behavioral Impairment (MBI) refers to a late life syndrome with prominent psychiatric and related behavioral symptoms in the absence of prominent cognitive symptoms, which may also be a dementia prodrome. To compare MCI and MBI patients and to estimate the risk of dementia development in these two groups. A consecutive series of 358 patients (239 with MCI; and 119 with MBI) presenting to an outpatient general hospital specialty clinic were followed for up to 5 years until conversion to dementia or censoring. 34% of MCI patients and over 70% of patients with MBI developed dementia (Logrank p=0.011). MBI patients without cognitive symptoms were more likely to develop dementia (Logrank p<0.001). MBI patients were more likely to develop dementia due to frontotemporal degeneration (FTD) as opposed to Alzheimer’s dementia (AD). MBI appears to be a transitional state between normal ageing and dementia. MBI (specifically those without cognitive symptoms) may confer a higher risk for dementia than MCI and is likely an FTD prodrome in many cases. These findings have implications for the early detection, prevention, and treatment of patients with dementia in late life, by focusing on the emergence of new behavioral symptoms.
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影响因子：
2.1
作者：
Hwang, TJ;Masterman, DL;Cummings, JL
通讯作者：
Cummings, JL
影响因子：
9.9
作者：
MCKHANN, G;DRACHMAN, D;STADLAN, EM
通讯作者：
STADLAN, EM
影响因子：
--
作者：
BECK, AT;ERBAUGH, J;MENDELSOHN, M
通讯作者：
MENDELSOHN, M
影响因子：
4.8
作者：
FOLSTEIN, MF;FOLSTEIN, SE;MCHUGH, PR
通讯作者：
MCHUGH, PR
影响因子：
--
作者：
Morris, JC;Storandt, M;Berg, L
通讯作者：
Berg, L