Inductively coupled, transmit-receive coils for proton MRI and X-nucleus MRI/MRS in small animals.
Inductively coupled, transmit-receive coils for proton MRI and X-nucleus MRI/MRS in small animals.
复制标题
用于小动物质子 MRI 和 X 核 MRI/MRS 的电感耦合发射-接收线圈。
DOI：
10.1016/j.jmro.2023.100123
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发表时间：
2023
影响因子：
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通讯作者：
Yen,Yi-Fen
中科院分区：
文献类型：
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作者：
Takahashi,AtsushiM;Sharma,Jitendra;Guarin,DavidO;Miller,Julie;Wakimoto,Hiroaki;Cahill,DanielP;Yen,Yi-Fen
我们报告了几种电感耦合射频线圈设计，它们非常容易构建，产生高信噪比（SNR）和高空间分辨率，同时适用于小动物的生命支持，麻醉和监测。设计了用于小鼠脑超极化13c磁共振成像（MRSI）的电感耦合表面线圈，重点是电路设计简单、易于使用、全脑覆盖和高信噪比。最简单的形式是一个谐振回路，设计在鼠标头的顶部，当电感耦合到宽带拾取线圈时，以高灵敏度实现对大脑的全覆盖。在这里，我们展示了线圈在正常小鼠和胶质母细胞瘤小鼠模型4.7 t的超极化13c磁共振成像中的表现，在大脑中获得了超过70:1的高信噪比，具有良好的空间分辨率（1.53 mm x 1.53 mm）。类似的电感耦合环可以很容易地在几分钟内制成其他x核，并达到高性能，如31p光谱所示。类似的设计概念被扩展到可分裂的电感耦合容积线圈，用于3T和9.4T的狨猴高分辨率质子MRI，以方便地适应头部约束、生命体征监测和麻醉输送。
We report several inductively coupled RF coil designs that are very easy to construct, produce high signal-to-noise ratio (SNR) and high spatial resolution while accommodating life support, anesthesia and monitoring in small animals. Inductively coupled surface coils were designed for hyperpolarized13C MR spectroscopic imaging (MRSI) of mouse brain, with emphases on the simplicity of the circuit design, ease of use, whole-brain coverage, and high SNR. The simplest form was a resonant loop designed to crown the mouse head for a snug fit to achieve full coverage of the brain with high sensitivity when inductively coupled to a broadband pick-up coil. Here, we demonstrated the coil's performance in hyperpolarized13C MRSI of a normal mouse and a glioblastoma mouse model at 4.7 T. High SNR exceeding 70:1 was obtained in the brain with good spatial resolution (1.53 mm x 1.53 mm). Similar inductively coupled loop for other X-nuclei can be made very easily in a few minutes and achieve high performance, as demonstrated in31P spectroscopy. Similar design concept was expanded to splitable, inductively coupled volume coils for high-resolution proton MRI of marmoset at 3T and 9.4T, to easily accommodate head restraint, vital-sign monitoring, and anesthesia delivery.