Synthesis of Selectively Mono-N-Arylated Aliphatic Diamines via Iridium-Catalyzed Amine Alkylation
Synthesis of Selectively Mono-N-Arylated Aliphatic Diamines via Iridium-Catalyzed Amine Alkylation
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DOI：
10.1002/adsc.200900548
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发表时间：
2009-11-01
影响因子：
5.4
通讯作者：
Kempe, Rhett
中科院分区：
文献类型：
--
作者：
Blank, Benoit;Michlik, Stefan;Kempe, Rhett
一个高选择性的磷/氮(P，N)配体Ir催化剂体系有效地催化芳胺与未保护的氨基醇的反应，生成N-芳基化脂肪族二胺，产率高达93%。该反应可与多种支链和直链氨基醇与各种氨基吡啶或取代苯胺结合进行。
A highly selective phosphorus/nitrogen (P,N) ligand-based iridium catalyst system efficiently catalyzes the reaction of arylamines with unprotected amino alcohols, yielding N-arylated aliphatic diamines in yields of up to 93%. The reaction can be performed with a wide variety of branched and linear amino alcohols in combination with various aminopyridines or substituted anilines.