Interactions between transient and sustained neural signals support the generation and regulation of anxious emotion.
Interactions between transient and sustained neural signals support the generation and regulation of anxious emotion.
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DOI：
10.1093/cercor/bhr373
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
L. Somerville;D. Wagner;G. Wig;J. Moran;P. Whalen;W. M. Kelley
中科院分区：
文献类型：
--
作者：
L. Somerville;D. Wagner;G. Wig;J. Moran;P. Whalen;W. M. Kelley
焦虑情绪可以在短暂的（威胁反应）和/或持续的（慢性忧虑和唤醒）时间尺度上表现出来，之前的工作表明这些信号是由可分离的神经回路支持的。这项功能磁共振成像研究在 55 名健康参与者中使用了混合块事件相关的情绪激发范式，同时测量短暂和持续的焦虑情绪反应，测试这些潜在不同系统的特异性和相互作用。结果表明，情绪处理网络的组成部分对短暂和持续的焦虑情绪特别敏感。杏仁核和中脑仅表现出短暂的反应，而腹侧基底前脑和前岛叶在长期情绪背景下表现出持续的活动，与任务诱发的焦虑呈正相关。较少的焦虑状态与腹内侧前额叶皮层的持续活动较多有关。此外，在不确定性测量的不耐受性方面得分较高的个体，腹内侧前额叶募集较低，这种募集不足预示着杏仁核对潜在威胁线索的短暂反应会更大。这项工作展示了大脑回路如何跨时间尺度相互作用以支持短暂和持续的焦虑情绪，并提出以短暂与持续的焦虑症状为标志的临床综合征的潜在不同机制。
Anxious emotion can manifest on brief (threat response) and/or persistent (chronic apprehension and arousal) timescales, and prior work has suggested that these signals are supported by separable neural circuitries. This fMRI study utilized a mixed block-event-related emotional provocation paradigm in 55 healthy participants to simultaneously measure brief and persistent anxious emotional responses, testing the specificity of, and interactions between, these potentially distinct systems. Results indicated that components of emotional processing networks were uniquely sensitive to transient and sustained anxious emotion. Whereas the amygdala and midbrain showed only transient responses, the ventral basal forebrain and anterior insula showed sustained activity during extended emotional contexts that tracked positively with task-evoked anxiety. States of lesser anxiety were associated with greater sustained activity in the ventromedial prefrontal cortex. Furthermore, ventromedial prefrontal recruitment was lower in individuals with higher scores on intolerance of uncertainty measures, and this hyporecruitment predicted greater transient amygdala responding to potential threat cues. This work demonstrates how brain circuitries interact across temporal scales to support brief and persistent anxious emotion and suggests potentially divergent mechanisms of dysregulation in clinical syndromes marked by brief versus persistent symptoms of anxiety.