Clinical Antibiotic-resistant Acinetobacter baumannii Strains with Higher Susceptibility to Environmental Phages than Antibiotic-sensitive Strains.
Clinical Antibiotic-resistant Acinetobacter baumannii Strains with Higher Susceptibility to Environmental Phages than Antibiotic-sensitive Strains.
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DOI：
10.1038/s41598-017-06688-w
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发表时间：
2017-07-24
影响因子：
4.6
通讯作者：
Tseng CC
中科院分区：
文献类型：
--
作者：
Chen LK;Kuo SC;Chang KC;Cheng CC;Yu PY;Chang CH;Chen TY;Tseng CC
抗生素耐药性鲍曼不动杆菌与全世界的医院感染有关。在这里，我们使用临床分离的鲍曼不动杆菌菌株作为模型来证明抗生素耐药性是否与噬菌体敏感性增加相关。本研究从不同环境中分离出24个能够感染鲍曼不动杆菌的活性噬菌体，并比较了抗生素敏感和抗生素耐药的鲍曼不动杆菌对不同噬菌体的敏感性。在我们的研究中，共鉴定出 403 株临床分离的鲍曼不动杆菌菌株。平均而言，抗生素耐药鲍曼不动杆菌菌株的噬菌体感染率为84%（从81%到86%），而抗生素敏感鲍曼不动杆菌菌株的感染百分比仅为56.5%（从49%到64%）。此外，对至少四种抗生素具有耐药性并表现出剂量依赖性反应的菌株中，鲍曼不动杆菌噬菌体感染的风险显着增加（p-trend < 0.0001）。在所有鲍曼不动杆菌分离株中，75.6% 可进行噬菌体分型。噬菌体分型的结果也可能揭示临床鲍曼不动杆菌菌株的抗生素耐药性。总之，噬菌体敏感性代表了鲍曼不动杆菌菌株的进化权衡，该菌株表现出对抗生素耐药性的适应，特别是在抗生素使用率较高的医疗环境中。
Antibiotic-resistant Acinetobacter baumannii is associated with nosocomial infections worldwide. Here, we used clinically isolated A. baumannii strains as models to demonstrate whether antibiotic resistance is correlated with an increased susceptibility to bacteriophages. In this study, 24 active phages capable of infecting A. baumannii were isolated from various environments, and the susceptibilities of both antibiotic-sensitive and antibiotic-resistant strains of A. baumannii to different phages were compared. In our study, a total of 403 clinically isolated A. baumannii strains were identified. On average, the phage infection percentage of the antibiotic-resistant A. baumannii strains was 84% (from 81–86%), whereas the infection percentage in the antibiotic-sensitive A. baumannii strains was only 56.5% (from 49–64%). In addition, the risk of phage infection for A. baumannii was significantly increased in the strains that were resistant to at least four antibiotics and exhibited a dose-dependent response (p-trend < 0.0001). Among all of the A. baumannii isolates, 75.6% were phage typeable. The results of phage typing might also reveal the antibiotic-resistant profiles of clinical A. baumannii strains. In conclusion, phage susceptibility represents an evolutionary trade-off in A. baumannii strains that show adaptations for antibiotic resistance, particularly in medical environments that have high antibiotic use.
暴露于噬菌体对药物浓度梯度上细菌抗生素耐药性的演变影响不大
影响因子：
4.1
作者：
Zhang QG
通讯作者：
Zhang QG