Endothelial mechanotransduction, nitric oxide and vascular inflammation
Endothelial mechanotransduction, nitric oxide and vascular inflammation
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DOI：
10.1111/j.1365-2796.2006.01621.x
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发表时间：
2006-04-01
影响因子：
11.1
通讯作者：
Searles, C
中科院分区：
文献类型：
--
作者：
Harrison, DG;Widder, J;Searles, C
血管稳态的许多方面都受到一氧化氮和活性氧（ROS）的调节。这些的产生受到施加在内皮和血管平滑肌上的机械力的显著影响。本文就机械力对内皮细胞一氧化氮合酶的表达、活性氧的产生以及谷胱甘肽的调节等方面的影响作一综述。我们还将回顾体内运动训练对内皮功能具有与层流剪切相似影响的数据，并讨论这些基本发现的临床相关性。
Numerous aspects of vascular homeostasis are modulated by nitric oxide and reactive oxygen species (ROS). The production of these is dramatically influenced by mechanical forces imposed on the endothelium and vascular smooth muscle. In this review, we will discuss the effects of mechanical forces on the expression of the endothelial cell nitric oxide synthase, production of ROS and modulation of endothelial cell glutathione. We will also review data that exercise training in vivo has a similar effect as laminar shear on endothelial function and discuss the clinical relevance of these basic findings.