Permanent draft genome sequence of the probiotic strain Propionibacterium freudenreichii CIRM-BIA 129 (ITG P20).
Permanent draft genome sequence of the probiotic strain Propionibacterium freudenreichii CIRM-BIA 129 (ITG P20).
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DOI：
10.1186/s40793-015-0120-z
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发表时间：
2016
影响因子：
--
通讯作者：
Le Loir Y
中科院分区：
文献类型：
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作者：
Falentin H;Deutsch SM;Loux V;Hammani A;Buratti J;Parayre S;Chuat V;Barbe V;Aury JM;Jan G;Le Loir Y
费氏丙酸杆菌属于放线菌纲（革兰氏阳性，GC含量高）。这种“公认安全”（GRAS）物种传统上用作（i）瑞士型奶酪的发酵剂，其中它负责产生孔和香味，（ii）白色生物技术中的维生素B12和丙酸生产者，以及（iii）由于其生物合成和抗炎特性而用于人类和动物的益生菌。到目前为止，只有菌株CIRM-BIA 1 T被测序、注释并公开。菌株CIRM-BIA 129（可作为ITG P20商购获得）具有相当大的抗炎潜力。将其基因含量与CIRM-BIA 1 T进行比较。该菌株含有2384个基因，其中核糖体操纵子1个，tRNA 45个，假基因30个。
Propionibacterium freudenreichii belongs to the class Actinobacteria (Gram positive with a high GC content). This “Generally Recognized As Safe” (GRAS) species is traditionally used as (i) a starter for Swiss-type cheeses where it is responsible for holes and aroma production, (ii) a vitamin B12 and propionic acid producer in white biotechnologies, and (iii) a probiotic for use in humans and animals because of its bifidogenic and anti-inflammatory properties. Until now, only strain CIRM-BIA1T had been sequenced, annotated and become publicly available. Strain CIRM-BIA129 (commercially available as ITG P20) has considerable anti-inflammatory potential. Its gene content was compared to that of CIRM-BIA1 T. This strain contains 2384 genes including 1 ribosomal operon, 45 tRNA and 30 pseudogenes.