The effects of age on steady-state pattern electroretinograms and visual evoked potentials
The effects of age on steady-state pattern electroretinograms and visual evoked potentials
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DOI：
10.1007/bf00161368
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发表时间：
2004
影响因子：
1.4
通讯作者：
H. Tomoda;G. Celesia;M. Brigell;S. Toleikis
中科院分区：
文献类型：
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作者：
H. Tomoda;G. Celesia;M. Brigell;S. Toleikis
同时记录两组青年和老年正常志愿者的稳态图形翻转视网膜电图和视觉诱发电位。年轻组由23名受试者（13名女性和10名男性）组成，年龄为18至28岁，老年组由24名受试者（11名女性和13名男性）组成，年龄为58至77岁。刺激方波光栅的空间频率范围从0.5到6 c/deg和相位反转的频率为4 Hz。图形反转视网膜电图和视觉诱发电位包括一个突出的第二和一个较小的第四谐波响应。年轻组和老年组的图形反转视网膜电图二次和四次谐波的空间频率-振幅函数相似。平均四次谐波相位在老年受试者与年轻受试者相比，显着转移的所有空间频率测试。观察两个年龄组的视觉诱发电位二次和四次谐波反应的振幅和相位函数的空间频率调谐。年龄对空间频率高于1.5 c/deg的相位有显著影响。老年组的四次谐波振幅显著较低，为1.5-4 c/deg。对于低于3 c/deg的空间频率，组间相位显著不同。我们的研究结果表明，老化影响视网膜和中央视觉通路。年龄差异影响视觉诱发电位的二次和四次谐波响应，这表明这些组件的不同神经元的起源。
Steady-state pattern-reversal electroretinograms and visual evoked potentials were simultaneously recorded in two groups of young and elderly normal volunteers. The young group consisted of 23 subjects (13 women and 10 men) aged 18 to 28 years, and the elderly group consisted of 24 subjects (11 women and 13 men) aged 58 to 77 years. Stimuli were square-wave gratings ranging in spatial frequency from 0.5 to 6 c/deg and phase reversed at a frequency of 4 Hz. Pattern-reversal electroretinograms and visual evoked potentials consisted of a prominent second and a smaller fourth harmonic response. Spatial frequency-amplitude functions of the pattern-reversal electroretinogram second and fourth harmonics were similar for the young and elderly groups. The mean fourth harmonic phase was significantly shifted in elderly subjects compared with young subjects for all spatial frequencies tested. Spatial frequency tuning was observed for amplitude and phase functions of the visual evoked potential second and fourth harmonic responses for both age groups. Age had a significant effect on phase for spatial frequencies above 1.5 c/deg. Amplitude of the fourth harmonic was significantly lower for the elderly group at 1.5–4 c/deg. Phase was significantly different between groups for spatial frequencies below 3 c/deg. Our results suggest that aging influences both retinal and central visual pathways. Aging differentially affected the visual evoked potential second and fourth harmonic responses, suggesting different neuronal origins for these components.