Control of papillomavirus DNA replication and transcription
Control of papillomavirus DNA replication and transcription
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DOI：
10.1006/scbi.1996.0043
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发表时间：
1996-12-01
影响因子：
14.5
通讯作者：
Demeret, C
中科院分区：
文献类型：
--
作者：
Desaintes, C;Demeret, C
HPV感染的特征包括对人上皮细胞的有限嗜性和与宿主角质形成细胞的分化程序紧密相关的病毒生命周期。由于缺乏合适的体外培养条件，这种特殊的病毒周期阻碍了HPV营养生命周期的研究数十年。组织与分化。依赖性似乎由病毒转录而不是病毒DNA复制决定。事实上，病毒转录仅限于人源上皮细胞，更具体地说是角质形成细胞。相反，HPV基因组可以在各种未分化的细胞系中复制，而不管它们对感染的天然容许性，只要病毒复制蛋白E1和E2表达。(C)1997年出版社有限公司。
Hallmarks of HPV infection include a restricted tropism for human epithelial cells and a viral life cycle tightly linked to the differentiation program of the host keratinocyte. This particular viral cycle has hampered the study of the HPV vegetative life cycle for decades, due to the lack of suitable in-vitro culture conditions. The tissue and differentiation. dependence seems to be dictated by viral transcription rather than viral DNA replication. Indeed, viral transcription is restricted to epithelial cells of human origin, more specifically to keratinocytes. In contrast, HPV genomes can replicate in various undifferentiated cell lines regardless of their natural permissiveness to infection, as long as the viral replication proteins E1 and E2 are expressed. (C) 1997 Academic Press Ltd.