Tracking the deformation of a tissue phantom induced by ultrasound-driven bubble oscillations
Tracking the deformation of a tissue phantom induced by ultrasound-driven bubble oscillations
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DOI：
10.1088/1742-6596/656/1/012006
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发表时间：
2015-12
期刊：
影响因子：
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通讯作者：
Marc Tinguely;O. Matar;V. Garbin
中科院分区：
文献类型：
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作者：
Marc Tinguely;O. Matar;V. Garbin
微泡在超声医学成像中用作造影剂。一旦微泡被注射到体内，它们就会通过粘弹性边界限制的血管系统流动。边界的接近程度以取决于边界的粘弹性性质的方式影响超声中气泡的动力学。关于剧烈破裂的气泡的实验揭示了血管壁变形的动力学。然而，与超声成像相关的小振幅振动气泡引起的形变场在实验中很难获得，目前还没有报道。我们提出了一种实验方法来测量的变形场所引起的气泡内的微通道内的组织模型振荡。我们使用高速视频显微镜来跟踪嵌入在幻影中的示踪剂颗粒的位移，沿着气泡的动态。
Microbubbles are used as contrast agents in ultrasound medical imaging. Once the microbubbles are injected into the body, they flow through the vascular system, confined by viscoelastic boundaries. The proximity of the boundaries affects the dynamics of the bubbles in ultrasound, in a manner that depends on the boundary's viscoelastic properties. Experiments on violently collapsing bubbles have revealed the dynamics of deformation of blood vessel walls. However, the deformation field induced by a bubble undergoing small-amplitude oscillations, relevant for ultrasound imaging, is difficult to access in experiment, and has not been reported yet. We present an experimental method to measure the deformation field induced by a bubble oscillating inside a microchannel within a tissue phantom. We use high-speed video microscopy to track the displacement of tracer particles embedded in the phantom, along with the dynamics of the bubble.