TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology
TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology
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DOI：
10.1101/cshperspect.a021873
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发表时间：
2016-05-01
影响因子：
7.2
通讯作者：
Miyazono, Kohei
中科院分区：
文献类型：
--
作者：
Morikawa, Masato;Derynck, Rik;Miyazono, Kohei
转化生长因子- β (tgf - β)是tgf - β生长分化因子家族的原型，在哺乳动物中由33个基因编码，包括同源和异源二聚体。这篇综述向读者介绍了tgf - β家族及其复杂的名称和生物活性。它还介绍了tgf - β作为tgf - β家族蛋白中研究得最好的因子，其在控制细胞增殖和分化，伤口愈合和免疫系统中的多样性作用，以及其在病理中的关键作用，例如骨骼疾病，纤维化和癌症。
The transforming growth factor-beta (TGF-beta) is the prototype of the TGF-beta family of growth and differentiation factors, which is encoded by 33 genes in mammals and comprises homo- and heterodimers. This review introduces the reader to the TGF-beta family with its complexity of names and biological activities. It also introduces TGF-beta as the best-studied factor among the TGF-beta family proteins, with its diversity of roles in the control of cell proliferation and differentiation, wound healing and immune system, and its key roles in pathology, for example, skeletal diseases, fibrosis, and cancer.