A region of mesial prefrontal cortex tracks monetarily rewarding outcomes: characterization with rapid event-related fMRI
A region of mesial prefrontal cortex tracks monetarily rewarding outcomes: characterization with rapid event-related fMRI
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DOI：
10.1016/s1053-8119(02)00057-5
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发表时间：
2003-02-01
期刊：
影响因子：
5.7
通讯作者：
Homme, D
中科院分区：
文献类型：
--
作者：
Knutson, B;Fong, GW;Homme, D
内侧前额叶皮层（MPFC：包括Brodman 10/12/32区）的功能仍然是一个谜。目前的理论认为，在代表内部信息，包括情绪内省，自主控制，和语义处理的“默认状态”的作用。最近的证据还表明，这一区域的部分区域也可能在处理奖励结果中发挥作用。在这项研究中，我们调查的可能性，该地区的MPFC将优先招募的货币奖励结果使用参数货币激励延迟（MID）任务。12名健康志愿者在玩MID任务时参与了功能性磁共振扫描。小组分析表明，虽然腹侧纹状体招募的预期货币奖励，MPFC的一个区域，而不是响应奖励的货币结果。具体而言，感兴趣的量分析表明，当志愿者收到5.00美元后，预计5.00美元的胜利，MPFC活动增加，而当志愿者没有收到5.00美元后，预计5.00美元的胜利，MPFC活动减少，相对于没有激励价值的结果。这些研究结果表明，在处理金钱奖励的背景下，MPFC的区域优先跟踪奖励的结果。(C)2003 Elsevier Science（美国）。All rights reserved.
The function of the mesial prefrontal cortex (MPFC: including Brodman areas 10/12/32) remains an enigma. Current theories suggest a role in representing internal information, including emotional introspection, autonomic control, and a "default state" of semantic processing. Recent evidence also suggests that parts of this region may also play a role in processing reward outcomes. In this study, we investigated the possibility that a region of the MPFC would be preferentially recruited by monetary reward outcomes using a parametric monetary incentive delay (MID) task. Twelve healthy volunteers participated in functional magnetic resonance scans while playing the MID task. Group analyses indicated that while the ventral striatum was recruited by anticipation of monetary reward, a region of the MPFC, instead responded to rewarding monetary outcomes. Specifically, volume-of-interest analyses indicated that when volunteers received $5.00 after anticipating a $5.00 win, MPFC activity increased, whereas when volunteers did not receive $5.00 after anticipating a $5.00 win, MPFC activity decreased, relative to outcomes with no incentive value. These findings suggest that in the context of processing monetary rewards, a region of the MPFC preferentially tracks rewarding outcomes. (C) 2003 Elsevier Science (USA). All rights reserved.