Gene structure and chromosome mapping of the human small-conductance calcium-activated potassium channel SK1 gene (KCNN1).
Gene structure and chromosome mapping of the human small-conductance calcium-activated potassium channel SK1 gene (KCNN1).
复制标题
人类小电导钙激活钾通道SK1基因（KCNN1）的基因结构和染色体定位。
DOI：
10.1159/000015415
复制
发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Adelman,JP
中科院分区：
文献类型：
--
作者：
Litt,M;LaMorticella,D;Bond,CT;Adelman,JP
小电导，钙活化的钾通道有助于中枢神经元和其他细胞类型的后超极化。由于这些通道调节神经元的兴奋性，它们的基因缺陷可能导致兴奋性障碍。人类cDNA编码一个这样的通道，SK1 (KCNN1)，最近被克隆。本文描述了KCNN1的基因结构及其在染色体19p13上的定位。1.
Small-conductance, calcium-activated potassium channels contribute to the afterhyperpolarization in central neurons and other cell types. Because these channels regulate neuronal excitability, defects in their genes could cause excitability disorders. The human cDNA encoding one such channel, SK1 (KCNN1), was recently cloned. Here we describe the gene structure of KCNN1 and its localization by radiation hybrid mapping to chromosome 19p13. 1.