Evaluation of a novel monoclonal antibody mAb109 by immuno-PET/fluorescent imaging for noninvasive lung adenocarcinoma diagnosis

Evaluation of a novel monoclonal antibody mAb109 by immuno-PET/fluorescent imaging for noninvasive lung adenocarcinoma diagnosis
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通过免疫-PET/荧光成像评价新型单克隆抗体 mAb109 用于无创肺腺癌诊断

DOI:
10.1038/s41401-019-0294-9
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发表时间:
2019-09
影响因子:
8.2
通讯作者:
杨志
杨志
中科院分区:
医学1区
文献类型:
--
作者:
朱华;刘特立;Changhao Liu;Jing Wang;Hong Zhang;董彬;Jing Shen;赵传科;Zhenfu Li;Zhen Cheng;杨志

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单克隆抗体被认为是神奇的子弹,在许多生物过程中具有巨大的潜力。免疫10 d后,mAb 109在5 × 106个细胞中表达量约为100 μg。合成了64 Cu-NOTA-mAb 109,
Monoclonal antibodies are believed to be magic bullets and hold great potential for lots of biological process. About 100 μg of mAb109 was expressed in 5 × 106 cells after 10 days’ immunization. 64Cu-NOTA-mAb109 was synthesized with the specific activity
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