Regulation of astroglial-derived dopaminergic neurotrophic factors by interleukin-1 beta in the striatum of young and middle-aged mice.
Regulation of astroglial-derived dopaminergic neurotrophic factors by interleukin-1 beta in the striatum of young and middle-aged mice.
复制标题
年轻和中年小鼠纹状体中白细胞介素-1β对星形胶质细胞衍生的多巴胺能神经营养因子的调节。
DOI：
10.1006/exnr.1997.6659
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Blum,M
中科院分区：
文献类型：
--
作者：
Ho,A;Blum,M
Interleukin-1β (IL-1β) can induce dopaminergic axonal sprouting in the denervated striatum of parkinsonian animals. In order to determine whether IL-1β effects on dopaminergic axonal sprouting are mediated by the induction of astroglial-derived dopaminergic neurotrophic factors, effects of IL-1β treatment on acidic and basic fibroblast growth factor (aFGF and bFGF) and glial cell line-derived growth factor (GDNF) gene expression were examined in primary striatal astrocyte cultures and afterin vivoadministration. We found a selective induction of bFGF mRNA synthesis but not aFGF or GDNF mRNA after IL-1β treatment bothin vitroandin vivo.This suggests that bFGF may be the putative endogenous dopaminergic neurotrophic factor mediating lesion-induced plasticity of dopamine neurons. In addition, to determine why recovery from injury becomes reduced with age, we examined whether there was an aging-associated decline in the ability of IL-1β to induce the synthesis of neurotrophic factors in middle-aged animals compared to young mice. Interestingly, IL-1β stimulated a greater induction in bFGF mRNA levels in the middle-aged mice compared to young mice. These results suggest that the regulation of bFGF and possibly its receptor signaling efficacy may vary as the brain ages.
