General and abdominal obesity and survival among young women with breast cancer
General and abdominal obesity and survival among young women with breast cancer
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DOI：
10.1158/1055-9965.epi-06-0356
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发表时间：
2006-10-01
影响因子：
3.8
通讯作者：
Coates, Ralph J.
中科院分区：
文献类型：
--
作者：
Abrahamson, Page E.;Gammon, Marilie D.;Coates, Ralph J.
在绝经后妇女中，肥胖与乳腺癌风险增加和随后生存率降低有关。对于绝经前妇女，肥胖可能会降低发病率，但其对预后的影响知之甚少，特别是腹型肥胖。本研究调查了诊断时全身或腹部肥胖是否影响一组年轻乳腺癌女性的生存率。一项基于人群的随访研究在1990年至1992年期间在亚特兰大或新泽西被诊断为浸润性乳腺癌的1,254名20至54岁的妇女中进行。妇女在诊断后的几个月内接受了采访，并询问了她们20岁时和诊断前一年的体重和身高。研究人员在访谈时进行人体测量。在8至10年的随访中，使用国家死亡指数（n = 290例死亡）确定全因死亡状态。与理想体重的女性相比，肥胖女性[体重指数（BMI），>= 30]的死亡率增加[BMI，18.5-24.9;分期和收入调整的风险比（HR），1.48; 95%置信区间（95%CI），1.09-2.01]。腰臀比的最高与最低四分位数也观察到类似的结果（HR，1.52; 95% CI，1.05-2.19）。在20岁时肥胖（HR，2.49; 95%CI，1.15-5.37）或在20岁和访谈时超重/肥胖（BMI，>= 25）的女性中，发现与死亡率有很强的相关性（HR，2.22; 95%CI，1.45-3.40）。这项研究提供的证据表明，乳腺癌生存率降低年轻妇女与一般或腹部肥胖。
Among postmenopausal women, obesity is linked to increased risk of breast cancer and poorer subsequent survival. For premenopausal women, obesity may reduce incidence, but less is known about its effect on prognosis, particularly for abdominal obesity. This study investigated whether general or abdominal obesity at diagnosis influenced survival in a cohort of young women with breast cancer. A population-based follow-up study was conducted among 1,254 women ages 20 to 54 who were diagnosed with invasive breast cancer between 1990 and 1992 in Atlanta or New Jersey. Women were interviewed within several months of diagnosis and asked about their weight and height at age 20 and in the year before diagnosis. Study personnel did anthropometric measures at the interview. With 8 to 10 years of follow-up, all-cause mortality status was determined using the National Death Index (n = 290 deaths). Increased mortality was observed for women who were obese [body mass index (BMI), >= 30] at the time of interview compared with women of ideal weight [BMI, 18.5-24.9; stage- and income-adjusted hazard ratio (HR), 1.48; 95% confidence interval (95% CI), 1.09-2.01]. A similar result was seen for the highest versus lowest quartile of waist-to-hip ratio (HR, 1.52; 95% CI, 1.05-2.19). Strong associations with mortality were found for women who were obese at age 20 (HR, 2.49; 95% CI, 1.15-5.37) or who were overweight/obese (BMI, >= 25) at both age 20 and the time of interview (HR, 2.22; 95% CI, 1.45-3.40). This study provides evidence that breast cancer survival is reduced among younger women with general or abdominal obesity.