Assessing exposure risks for aquatic organisms posed by Tamiflu use under seasonal influenza and pandemic conditions
Assessing exposure risks for aquatic organisms posed by Tamiflu use under seasonal influenza and pandemic conditions
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DOI：
10.1016/j.envpol.2013.09.019
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发表时间：
2014-01-01
影响因子：
8.9
通讯作者：
Liao, Chung-Min
中科院分区：
文献类型：
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作者：
Chen, Wei-Yu;Lin, Chia-Jung;Liao, Chung-Min
抗流感药物造成的环境污染越来越被认为是对水生环境的威胁。然而，鲜为人知的是，根据最近发表的生态毒理学研究在台湾的抗流感药物的环境相关浓度所造成的风险影响的经验数据。在这里，我们将生态毒理学模型与流行病学计划相结合，以评估台湾使用抗病毒药物奥司他韦（达菲）对水生生物和环境造成的危害。基于已发表的生物测定，我们使用概率风险评估模型来估计环境相关危害对藻类、水蚤和斑马鱼的潜在威胁。我们发现，在季节性流感期间，达菲的使用不太可能对水蚤和斑马鱼造成重大的慢性环境风险。然而，在大流行期间使用达菲造成的长期环境风险令人担忧。我们的结论是，在季节性流感和高流行性达菲使用期间，没有发现藻类生长的重大风险。(C)2013爱思唯尔有限公司保留所有权利。
Environmental pollution by anti-influenza drugs is increasingly recognized as a threat to aquatic environments. However, little is known about empirical data on risk effects posed by environmentally relevant concentrations of anti-influenza drug based on recently published ecotoxicological researches in Taiwan. Here we linked ecotoxicology models with an epidemiological scheme to assess exposure risks of aquatic organisms and environmental hazards posed by antiviral oseltamivir (Tamiflu) use in Taiwan. Built on published bioassays, we used probabilistic risk assessment model to estimate potential threats of environmentally relevant hazards on algae, daphnid, and zerbrafish. We found that Tamiflu use was unlikely to pose a significant chronic environmental risk to daphnia and zebrafish during seasonal influenza. However, the chronic environmental risk posed by Tamiflu use during pandemic was alarming. We conclude that no significant risk to algal growth was found during seasonal influenza and high pandemic Tamiflu use. (C) 2013 Elsevier Ltd. All rights reserved.