INTERLEUKIN-3 SUPPORTS GROWTH OF MOUSE PRE-B-CELL CLONES INVITRO
INTERLEUKIN-3 SUPPORTS GROWTH OF MOUSE PRE-B-CELL CLONES INVITRO
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DOI：
10.1038/309126a0
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发表时间：
1984-01-01
期刊：
影响因子：
64.8
通讯作者：
MCKEARN, JP
中科院分区：
文献类型：
--
作者：
PALACIOS, R;HENSON, G;MCKEARN, JP
由于无法在体外维持同质的前体细胞群体，对产生 Ig 的 B 淋巴细胞的分化研究受到阻碍。白细胞介素 3 支持新鲜分离的胎儿[小鼠]肝脏前 B 细胞的生长以及白细胞介素 3 依赖性前 B 细胞克隆的长期培养，这些克隆可以在体外诱导成熟为抗体分泌细胞。
Study of the differentiation of Ig-producing B lymphocytes was hampered by the inability to maintain homogeneous populations of precursor cells in vitro. Interleukin 3 supports the growth of freshly isolated fetal [mouse] liver pre-B cells and the long-term culture of interleukin 3 dependent pre-B cell clones that can be induced to mature into antibody secreting cells in vitro.