Update on the glomerular filtration barrier.
Update on the glomerular filtration barrier.
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DOI：
10.1097/mnh.0b013e3283296044
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发表时间：
2009-05
影响因子：
3.2
通讯作者：
Miner JH
中科院分区：
文献类型：
--
作者：
Jarad G;Miner JH
肾脏学界对蛋白质通过肾小球毛细血管壁（GCW）的筛分缺乏统一的观点。GCW由三个不同但密切相互作用的层组成：有孔内皮及其糖萼;足细胞及其叉指状足突和狭缝隔膜;以及介于其间的肾小球基底膜（GBM）。蛋白尿与任何一层的异常有关，表明每一层都有助于肾小球滤过屏障（GFB）。蛋白尿也可以在正常GCW的情况下诱导。在这里，我们回顾了一些经典的研究，以及一些较新的概念，并提出了竞争的假设GFB。最近出现了两个几乎被遗忘的概念。一个研究小组质疑GFB对白蛋白的精确选择性，并提出蛋白尿是肾小管摄取异常的结果。还重新强调通过GBM的扩散作为大分子过滤背后的驱动力。新的证据表明，内皮糖萼是一个重要的电荷选择性屏障。我们建议将GFB视为动态屏障而不是刚性屏障，需要三个健康层和血流动力学稳定状态。研究内皮、白蛋白的肾小管处理和血液动力学作用的多重挑战将需要新的工具、新的假设和开放的思想。
The nephrology community lacks a unified view of protein sieving through the glomerular capillary wall (GCW). The GCW consists of three distinct but closely interacting layers: the fenestrated endothelium, with its glycocalyx; the podocytes, with their interdigitated foot processes and slit diaphragms; and the intervening glomerular basement membrane (GBM). Proteinuria is associated with abnormalities in any one layer, suggesting that each contributes to the glomerular filtration barrier (GFB). Proteinuria can also be induced in the context of a normal GCW. Here we review some classic studies as well as some newer concepts and present competing hypotheses about the GFB. Two almost forgotten concepts have recently emerged. One group has challenged the exquisite selectivity of the GFB to albumin and suggested that proteinuria is the result of abnormal tubular uptake. There has also been a reemphasis on diffusion through the GBM as the driving force behind macromolecular filtration. New evidence suggests that the endothelial glycocalyx is an important charge-selective barrier. We suggest viewing the GFB as a dynamic rather than as a rigid barrier, requiring three healthy layers and a hemodynamic steady state. Multiple challenges to studying the endothelium, the tubular handling of albumin, and the role of hemodynamic forces will require new tools, new hypotheses, and open minds.
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DOI：
10.1083/jcb.7.2.297
发表时间：
1960-04
期刊：
The Journal of biophysical and biochemical cytology
影响因子：
--
作者：
FARQUHAR MG;PALADE GE
通讯作者：
PALADE GE
影响因子：
158.5
作者：
Eremina, Vera;Jefferson, J. Ashley;Quaggin, Susan E.
通讯作者：
Quaggin, Susan E.
影响因子：
15.9
作者：
CHANG, RLS;DEEN, WM;BRENNER, BM
通讯作者：
BRENNER, BM
影响因子：
6.3
作者：
Asgeirsson, D.;Venturoli, D.;Rippe, C.
通讯作者：
Rippe, C.
影响因子：
6
作者：
Greive, KA;Nikolic-Paterson, DJ;Comper, WD
通讯作者：
Comper, WD