Meal-induced insulin secretion in dogs is mediated by both branches of the autonomic nervous system.
Meal-induced insulin secretion in dogs is mediated by both branches of the autonomic nervous system.
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狗的膳食诱导的胰岛素分泌是由自主神经系统的两个分支介导的。
DOI：
10.1152/ajpendo.2000.278.4.e603
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
TaborskyJr,GJ
中科院分区：
文献类型：
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作者：
Benthem,L;Mundinger,TO;TaborskyJr,GJ
我们研究了慢性插管犬在进食时、进食时和吸收早期胰腺自主活动与胰岛素分泌之间的关系。胰多肽（PP）输出，胰腺去甲肾上腺素溢出（PNESO），和动脉肾上腺素（Epi）分别作为胰腺的副交感神经和交感神经活动和肾上腺髓质活动的指标。自主神经活动与胰岛素分泌的关系已被自主神经阻滞所证实。向犬展示食物引发胰岛素分泌的短暂增加，而不改变PP输出或PNESO。Epi确实增加，表明β2-肾上腺素能介导，这被β-肾上腺素受体阻滞证实。进食引发了第二次短暂的胰岛素反应，这只能被毒蕈碱和β-肾上腺素受体阻滞剂完全消除。在吸收过程中，胰岛素增加到一个平台。PP输出表现出相同的模式，表明副交感神经的调解。PNESO降低50%，表明抑制性交感神经张力的撤回。我们的结论是：（1）胰岛素对食物的反应是由Epi的β2-肾上腺素能效应介导的;（2）胰岛素对进食的反应是由副交感神经毒蕈碱刺激和Epi的β2-肾上腺素能效应共同介导的;（3）胰岛素在吸收早期的反应是由副交感神经激活介导的，可能有交感神经张力的消退。
We investigated the relationship between autonomic activity to the pancreas and insulin secretion in chronically catheterized dogs when food was shown, during eating, and during the early absorptive period. Pancreatic polypeptide (PP) output, pancreatic norepinephrine spillover (PNESO), and arterial epinephrine (Epi) were measured as indexes for parasympathetic and sympathetic nervous activity to the pancreas and for adrenal medullary activity, respectively. The relation between autonomic activity and insulin secretion was confirmed by autonomic blockade. Showing food to dogs initiated a transient increase in insulin secretion without changing PP output or PNESO. Epi did increase, suggesting β2-adrenergic mediation, which was confirmed by β-adrenoceptor blockade. Eating initiated a second transient insulin response, which was only totally abolished by combined muscarinic and β-adrenoceptor blockade. During absorption, insulin increased to a plateau. PP output showed the same pattern, suggesting parasympathetic mediation. PNESO decreased by 50%, suggesting withdrawal of inhibitory sympathetic neural tone. We conclude that1) the insulin response to showing food is mediated by the β2-adrenergic effect of Epi,2) the insulin response to eating is mediated both by parasympathetic muscarinic stimulation and by the β2-adrenergic effect of Epi, and3) the insulin response during early absorption is mediated by parasympathetic activation, with possible contribution of withdrawal of sympathetic neural tone.