Effects of Buyang Huanwu decoction on peripheral nerve regeneration using silicone rubber chambers
Effects of Buyang Huanwu decoction on peripheral nerve regeneration using silicone rubber chambers
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DOI：
10.1142/s0192415x01000447
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发表时间：
2001-01-01
影响因子：
5.7
通讯作者：
Tsai, C
中科院分区：
文献类型：
--
作者：
Chen, YS;Cheng, WC;Tsai, C
本研究观察补阳还五汤对大鼠坐骨神经近端和远端10 mm缝合缝合硅橡胶管后再生的影响，并以空白硅橡胶管为对照。植入6周后，口服补阳还五汤的动物有89%的动物神经间隙再生，而对照组只有70%的动物再生。再生神经的定性和定量组织学观察显示，补阳还五组再生神经超微结构更加成熟，有髓轴突数量、神经内膜面积、轴突密度和轴突面积占神经总面积的百分比均显著高于对照组。提示补阳还五汤对再生神经有促进生长的作用。
This study investigated the effect of Buyang Huanwu decoction on the regeneration of a 10-mm gap of rat sciatic nerve created between the proximal and distal nerve stumps, which were sutured into silicone rubber tubes, Empty silicone rubber tubes with no further treatment were used as controls. Six weeks after implantation, 89% of the animals orally administered the Buyang Huanwu decoction exhibited regeneration across the nerve gaps, whereas only 70% had regenerated in the control group. Both qualitative and quantitative histology of the regenerated nerves revealed a more mature ultrastructural organization with significantly higher numbers of myelinated axons, larger endoneurial areas, higher axon densities and a larger percentage of axon area per total nerve area in the Buyang Huanwu group than in the controls. These results showed that the Buyang Huanwu decoction had a growth-promoting effect on the regenerated nerves.