High potency vaccines induce protection against heterologous challenge with foot-and-mouth disease virus
High potency vaccines induce protection against heterologous challenge with foot-and-mouth disease virus
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DOI：
10.1016/j.vaccine.2008.01.038
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发表时间：
2008-03-20
期刊：
影响因子：
5.5
通讯作者：
Haas, B.
中科院分区：
文献类型：
--
作者：
Brehm, K. E.;Kumar, N.;Haas, B.
在一系列的3个同源和8个异源攻毒实验中，结果表明，高效甲型口蹄疫疫苗即使对低r值病毒的异源攻毒感染也能产生保护作用。攻毒当天（疫苗接种后21天）的攻毒病毒特异性中和抗体反应通常与保护相关。(C) 2008 Elsevier Ltd版权所有。
In a series of three homologous and eight heterologous challenge experiments, it was shown that high potency vaccines against foot-and-mouth disease (FMD) serotype A can induce protection even against heterologous challenge infection with viruses that give low r-values with the vaccine strains. The challenge virus specific neutralizing antibody response on the day of challenge (21 days post vaccination) generally correlated with protection. (C) 2008 Elsevier Ltd. All rights reserved.