Pathogen resistance and immunocompetence covary with social status in house finches (Carpodacus mexicanus)
Pathogen resistance and immunocompetence covary with social status in house finches (Carpodacus mexicanus)
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DOI：
10.1111/j.1365-2435.2007.01254.x
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发表时间：
2007-06-01
影响因子：
5.2
通讯作者：
Dhondt, A. A.
中科院分区：
文献类型：
--
作者：
Hawley, D. M.;Jennelle, C. S.;Dhondt, A. A.
1.社会地位对个体生理有显著影响，但其对病原菌抗性的影响程度却鲜有人探讨。在这里，我们研究了越冬家雀(Carpodacus Micianus)群体中的社会地位如何与免疫能力和对传染病的易感性有关。我们分析了免疫反应的细胞和体液成分，然后量化了实验感染鸡败血支原体后的症状严重程度，鸡败支原体是一种自然发生的细菌病原体，会在北美各地的家雀社会聚集地引起周期性的流行病。群居优势的家雀对植物血凝素的免疫反应较强，但对绵羊红细胞的抗体滴度较弱。接种鸡败血型支原体后，优势雄鼠的症状严重程度和出现症状的时间比例显著降低，而雌鼠则不明显。个人状况与感染前或感染后的社会地位无关，但感染鸡毒杆菌会在不同社会地位之间造成资源获取的差异。感染后雌雄优势鸟的采食时间间隔均显著长于受感染的下级鸟。资源获取的变化可能在一定程度上是观察到的社会地位和疾病严重性之间的关系的基础，但检测到的特定性别的相互作用表明内分泌-免疫关系的作用值得进一步研究。总体而言，我们的结果表明，社会行为可以影响免疫能力和对一种在野外具有广泛影响的传染病的抵抗力，这突显了在研究自然人口中的疾病时考虑个人的社会背景的重要性。
1. Social status has striking effects on individual physiology, but the extent to which it influences pathogen resistance has rarely been explored. Here we examine how social status within groups of wintering house finches (Carpodacus mexicanus) relates to immunocompetence and susceptibility to an infectious disease.2. We assayed cellular and humoral components of the immune response, then quantified symptom severity in response to experimental infection with Mycoplasma gallisepticum, a naturally occurring bacterial pathogen that causes periodic epidemics in social aggregations of house finches across North America.3. Socially dominant house finches mounted stronger immune responses to phytohaemagglutinin but weaker antibody titres to sheep red blood cells. Dominant males, but not females, showed significantly lower symptom severity and proportion of time symptomatic when inoculated with M. gallisepticum.4. Individual condition was not associated with social status before or after infection, but infection with M. gallisepticum created disparities in resource access across social status. Infected dominant birds of both sexes fed for significantly more time intervals than infected subordinate birds following infection.5. Changes in resource access may partly underlie observed relationships between social status and disease severity, but the detected sex-specific interactions suggest a role for endocrine-immune relationships that warrant further study. Overall, our results indicate that social behaviour can influence both immunocompetence and resistance to an infectious disease of broad impact in the wild, highlighting the importance of considering the social context of individuals in studies of disease in natural populations.