EFFECT OF PHOSPHONOACETIC ACID ON HERPES VIRUSES
EFFECT OF PHOSPHONOACETIC ACID ON HERPES VIRUSES
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DOI：
10.1093/jac/3.suppl_a.63
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发表时间：
1977-01-01
影响因子：
5.2
通讯作者：
SUBAKSHARPE, JH
中科院分区：
文献类型：
--
作者：
HAY, J;BROWN, SM;SUBAKSHARPE, JH
理想的抗病毒剂是在抑制病毒生长的同时，对宿主细胞几乎没有毒性作用的药物。这种具有抗疱疹病毒活性的化合物似乎是存在的，这是由Shipkowitz等人首先证明的。（1973），他在随机筛选实验中发现了膦酰基乙酸（PAA）的抗病毒活性。这些早期发现表明，该化合物对单纯疱疹病毒（如小鼠疱疹性皮炎和兔疱疹性角膜炎）具有活性，对动物本身几乎没有明显的严重影响。福克斯博士在本增刊的其他地方讨论了化学结构的细节。
The ideal antiviral agent would be one which, while inhibiting growth of the virus, had little or no toxic effect on a host cell. That such a compound with anti herpes virus activity appeared to exist was first shown by Shipkowitz et al.(1973) who in random screening experiments discovered the antiviral activity of phosphonoacetic acid (PAA). These early findings indicated that the compound was active against herpes simplex virus as herpes dermatitis in mice and herpes keratitis in rabbits, with little apparently serious effect on the animals themselves. Details of chemical structure are discussed by Dr Fox elsewhere in this supplement.