Contributions of amygdala and striatal activity in emotion regulation
Contributions of amygdala and striatal activity in emotion regulation
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DOI：
10.1016/j.biopsych.2004.12.038
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发表时间：
2005-03-15
影响因子：
10.6
通讯作者：
Casey, BJ
中科院分区：
文献类型：
--
作者：
Hare, TA;Tottenham, N;Casey, BJ
背景：情绪信息可以促进或干扰认知过程。在这项研究中，我们研究了情绪的影响。信息的偏见性能和生物学基础的这种影响。方法：10名人类受试者（5名女性）进行功能性磁共振成像扫描，而执行的情绪去/不去，task.Results：主题是缓慢的方法恐惧的目标表情，并有更多的困难，避免快乐的非目标表情。杏仁核在负性情绪情境中被激活最多，当检测到负性表情时，该区域的活动与反应时间呈正相关。增加信号在右侧尾状核观察时，避免nontargets和呈负相关的假警报subjects.Conclusions的数量：情绪的背景下，可以改变接近或避免刺激时的行为和生物反应。我们发现，杏仁核（一个与评估情绪意义有关的区域）的募集与接近负面信息时更长的反应潜伏期有关，而尾状核（一个先前与奖励和冲动控制有关的结构）的募集在避免正面信息时最活跃。我们的研究结果对夸大和抑制情绪反应具有重要意义，这些情绪反应是许多精神疾病的特征。
Background: Emotional information can facilitate or interfere with cognitive processes. In this study, we examined the influence of emotional. information in biasing performance and the biological basis underlying this influence.Methods: Ten human subjects (five female) were scanned with functional magnetic resonance imaging while performing an emotional go/nogo, task.Results: Subjects were slower to approach fearful target expressions and had more difficulty avoiding happy nontarget expressions. The amygdala was recruited most for negative emotional context, and activity in this region was positively correlated with response time when detecting negative expressions. Increased signal in the right caudate nucleus was observed when avoiding nontargets and was negatively correlated with the number of false alarms subjects made.Conclusions: Emotional context can alter behavioral and biological responses when approaching or avoiding a stimulus. We showed that recruitment of the amygdala, a region implicated in evaluating emotional significance, was associated with longer response latencies when approaching negative information, whereas recruitment of the caudate nucleus, a structure previously implicated in reward and impulse control, was most active when avoiding positive information. Our findings have significant implications for exaggerated and inhibited emotional responses that are characteristic of a number of psychiatric disorders.