c-Maf suppresses human T-cell leukemia virus type 1 Tax by competing for CREB-binding protein
c-Maf suppresses human T-cell leukemia virus type 1 Tax by competing for CREB-binding protein
复制标题
c-Maf 通过竞争 CREB 结合蛋白抑制人类 T 细胞白血病病毒 1 型 Tax
DOI：
10.1111/j.1349-7006.2011.01873.x
复制
发表时间：
2011
期刊：
影响因子：
5.7
通讯作者：
Yoshie O
中科院分区：
文献类型：
--
作者：
Hieshima K;Nagakubo D;Shigeta A;Tanaka Y;Hoshino H;Tsukasaki K;Yamada Y;Yoshie O
人类T细胞白血病病毒1型（HTLV-1）的潜伏感染被认为优先与CCR 4 + CD 4 +T细胞相关。在这里，我们报告了c-Maf，Th 2分化的关键转录因子之一，通过竞争CREB结合蛋白抑制HTLV-1 Tax的转录活性。值得注意的是，c-maf表达在活化后的一部分CCR 4 + CD 4 +T细胞中被选择性诱导。此外，c-Maf显著降低Tax诱导的HTLV-1感染性HTLV-1分子克隆中的HTLV-1 β egp 46基因表达和无细胞HTLV-1感染系统中的Tax表达。总的来说，c-Maf可能通过负调节Tax活性在CCR 4 + CD 4 +T细胞中HTLV-1的潜伏感染中发挥作用。（Cancer Sci2011; 102：890-894）
Latent infection of human T‐cell leukemia virus type 1 (HTLV‐1) is considered to be preferentially associated with CCR4+CD4+T cells. Here we report that c‐Maf, one of the critical transcription factors for Th2 differentiation, suppresses the transcriptional activity of HTLV‐1 Tax by competing for CREB‐binding protein. Notably,c‐mafexpression is selectively induced in a fraction of CCR4+CD4+T cells upon activation. Furthermore, c‐Maf significantly decreases Tax‐induced HTLV‐1 envelopegp46gene expression from an infectious HTLV‐1 molecular clone andtaxexpression in a cell‐free HTLV‐1 infection system. Collectively, c‐Maf may play a role in latent infection of HTLV‐1 in CCR4+CD4+T cells by negatively regulating Tax activity. (Cancer Sci2011; 102: 890–894)