Definition and classification of chronic kidney disease: A position statement from Kidney Disease: Improving Global Outcomes (KDIGO)
Definition and classification of chronic kidney disease: A position statement from Kidney Disease: Improving Global Outcomes (KDIGO)
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DOI：
10.1111/j.1523-1755.2005.00365.x
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发表时间：
2005-06-01
影响因子：
19.6
通讯作者：
Eknoyan, G
中科院分区：
文献类型：
--
作者：
Levey, AS;Eckardt, KU;Eknoyan, G
慢性肾脏病（CKD）是一个全球性的公共卫生问题，具有肾衰竭、心血管疾病（CVD）和过早死亡的不良后果。肾脏疾病的简单定义和分类对于国际临床实践指南的制定和实施是必要的。肾脏疾病：改善全球结局（KDIGO）进行了一项调查，并赞助了一次争议会议，以（1）为肾脏病质量结局倡议（K/DOQI）推荐的定义和分类的证据基础提供肾脏病学和非肾脏病学社区的清晰理解，（2）为采用简单的定义和分类系统达成全球共识，以及（3）确定合作研究议程和计划，以改善证据基础并促进CKD定义和分类的实施。K/DOQI定义和分类被接受，但需要澄清。CKD定义为肾损害或三个点尿标本中有两个的肾小球滤过率（GFR）30 mg/g。GFR可以通过校准的血清肌酐和估算公式估算，如肾脏疾病饮食改良（MDRD）研究公式或Cockcroft-Gault公式。根据GFR的水平，肾脏疾病的严重程度分为五个阶段。应注意肾脏疾病的透析和移植治疗。应根据病因和肾脏疾病进展和CVD的风险制定简单、统一的CKD分类。
Chronic kidney disease (CKD) is a worldwide public health problem, with adverse outcomes of kidney failure, cardiovascular disease (CVD), and premature death. A simple definition and classification of kidney disease is necessary for international development and implementation of clinical practice guidelines. Kidney Disease: Improving Global Outcomes (KDIGO) conducted a survey and sponsored a controversies conference to (1) provide a clear understanding to both the nephrology and nonnephrology communities of the evidence base for the definition and classification recommended by Kidney Disease Quality Outcome Initiative (K/DOQI), (2) develop global consensus for the adoption of a simple definition and classification system, and (3) identify a collaborative research agenda and plan that would improve the evidence base and facilitate implementation of the definition and classification of CKD.The K/DOQI definition and classification were accepted, with clarifications. CKD is defined as kidney damage or glomerular filtration rate (GFR) 30 mg/g in two of three spot urine specimens. GFR can be estimated from calibrated serum creatinine and estimating equations, such as the Modification of Diet in Renal Disease (MDRD) Study equation or the Cockcroft-Gault formula. Kidney disease severity is classified into five stages according to the level of GFR. Kidney disease treatment by dialysis and transplantation should be noted. Simple, uniform classifications of CKD by cause and by risks for kidney disease progression and CVD should be developed.