Circulating Sclerostin Levels and Markers of Bone Turnover in Chinese-American and White Women
Circulating Sclerostin Levels and Markers of Bone Turnover in Chinese-American and White Women
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DOI：
10.1210/jc.2013-2106
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发表时间：
2013-12-01
影响因子：
5.8
通讯作者：
Bilezikian, John P.
中科院分区：
文献类型：
--
作者：
Costa, Aline G.;Walker, Marcella D.;Bilezikian, John P.
背景：与白人女性相比，华裔美国女性具有骨微结构特征，导致骨硬度更大，但这些发现背后的生理学尚未得到调查。目的：本研究的目的是评估血清硬化素和骨转换标志物 (BTM) 的种族差异，并探讨它们之间的关系、体积骨矿物质密度 (BMD) 和华裔美国女性和白人女性的骨微结构。设计和背景：我们在一所大学进行了一项横断面研究医院。参与者：我们研究了 138 名女性。结果：绝经前和绝经后的华裔美国女性与白人女性相比，血清骨钙素分别低 19-28%（均 P < .01）。与白人女性相比，绝经前和绝经后的华裔美国女性的 I 型胶原蛋白 C 端端肽 (CTX) 水平低 18-22%（均 P < .05）。与华裔美国女性相比，白人女性绝经后骨钙素和 CTX 的差异更大。两个种族的硬化素水平相似，但 BTM 与种族和绝经状态的硬化素的相关性存在差异。在华裔美国人中，BTM 与硬化蛋白不相关。在白人绝经前女性中，CTX 和骨特异性碱性磷酸酶与硬化素呈正相关（r = 0.353，r = 0.458；均 P < .05）。相比之下，在绝经后白人女性中，硬化蛋白与 I 型前胶原氨基末端前肽、抗酒石酸酸性磷酸酶同工型 5b 和 CTX 呈阴性关系（所有 P < .05）。调整协变量后，硬化素与两个种族的面积 BMD 均呈正相关。结论：华裔美国女性的 BTM 较低，而白人女性的 BTM 与年龄相关的差异较大，这为解释 BMD、微结构和骨折方面的种族差异提供了一个生理框架。
Context: Chinese-American women have bone microarchitectural features that confer greater bone stiffness compared to white women, but the physiology underlying these findings has not been investigated.Objective: The purpose of the study was to assess racial differences in serum sclerostin and bone turnover markers (BTMs), and to explore their associations with each other, volumetric bone mineral density (BMD), and bone microarchitecture in Chinese-American and white women.Design and Setting: We conducted a cross-sectional study at a university hospital.Participants: We studied 138 women.Results: Serum osteocalcin was 19-28% lower in pre- and postmenopausal Chinese-American vs white women, respectively (both P < .01). C-Terminal telopeptide of type I collagen (CTX) level was 18-22% lower in pre- and postmenopausal Chinese-American vs white women (both P < .05). Prevs postmenopausal differences in osteocalcin and CTX were greater in white vs Chinese-American women. Sclerostin levels were similar in both races, but BTMs were differentially associated with sclerostin by race and menopausal status. BTMs were not correlated with sclerostin in Chinese-Americans. CTX and bone-specific alkaline phosphatase were positively associated with sclerostin (r = 0.353, r = 0.458; both P < .05) in white premenopausal women. In contrast, in postmenopausal white women, the associations of sclerostin with amino-terminal propeptide of type I procollagen, isoform 5b of tartrate-resistant acid phosphatase, and CTX were negative (all P < .05). Adjusting for covariates, sclerostin was positively associated with areal BMD in both races.Conclusions: Lower BTMs in Chinese-American women and greater age-related differences in BTMs among white women provide a physiological framework to account for racial differences in BMD, microarchitecture, and fracture.