First evidence of phase-contrast imaging with laboratory sources and active pixel sensors
First evidence of phase-contrast imaging with laboratory sources and active pixel sensors
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DOI：
10.1016/j.nima.2007.08.154
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发表时间：
2007-11-01
影响因子：
1.4
通讯作者：
Speller, R. D.
中科院分区：
文献类型：
--
作者：
Olivo, A.;Arvanitis, C. D.;Speller, R. D.
本工作的目的是将一种创新的x射线成像技术-相对比成像（XPCi）的优势与一类新型传感器（即基于cmos的有源像素传感器（aps））的优势结合起来，迈出第一步。XPCi的优势是众所周知的，包括提高图像质量和检测传统技术不可见的细节，潜在的应用领域包括医疗、生物、工业和安全领域。香草，由MI-3合作开发的aps之一（见http://mi3.shef.ac.uk），被彻底表征，并选择了一个适当的闪烁体来提供x射线灵敏度。在此过程中，采用成熟的自由空间传播XPCi技术获得了一组不同生物样品的相衬图像。所得结果非常令人鼓舞，与一些作者最近开发的模拟预测非常吻合，从而进一步支持了其可靠性。本文详细介绍了这些初步结果，并简要讨论了这项工作的背景和未来的发展。(c) 2007 Elsevier B.V.版权所有
The aim of the present work is to achieve a first step towards combining the advantages of an innovative X-ray imaging technique - phase-contrast imaging (XPCi) - with those of a new class of sensors, i.e. CMOS-based active pixel sensors (APSs). The advantages of XPCi are well known and include increased image quality and detection of details invisible to conventional techniques, with potential application fields encompassing the medical, biological, industrial and security areas.Vanilla, one of the APSs developed by the MI-3 collaboration (see http://mi3.shef.ac.uk), was thoroughly characterised and an appropriate scintillator was selected to provide X-ray sensitivity. During this process, a set of phase-contrast images of different biological samples was acquired by means of the well-established free-space propagation XPCi technique. The obtained results are very encouraging and are in optimum agreement with the predictions of a simulation recently developed by some of the authors thus further supporting its reliability. This paper presents these preliminary results in detail and discusses in brief both the background to this work and its future developments. (c) 2007 Elsevier B.V. All rights reserved.