HIV infection alters the human epigenetic landscape
HIV infection alters the human epigenetic landscape
复制标题
HIV感染改变人类表观遗传景观
DOI：
10.1038/s41434-018-0051-6
复制
发表时间：
2019-02-01
期刊：
影响因子：
5.1
通讯作者：
Cai, Yu-Dong
中科院分区：
文献类型：
--
作者：
Chen, Lei;Zhang, Shiqi;Cai, Yu-Dong
许多复杂的疾病或特征是遗传和环境因素共同作用的结果。环境因素通过改变表观遗传学来影响人体，表观遗传学控制基因组的活性而不使其发生突变，病毒感染是复杂疾病的常见环境因素之一。例如，人免疫缺陷病毒（HIV）感染可引起获得性免疫缺陷综合征（AIDS），HBV和HCV感染与肝细胞癌有关，而人乳头瘤病毒感染是宫颈癌的致病因素。在这项研究中，为了研究HIV感染如何影响DNA甲基化，我们分析了44名HIV-和142名HIV +患者的485512个位点的血液DNA甲基化数据。应用几种先进的计算方法来识别HIV患者和健康对照之间的核心区别特征。这些方法可用于区分HIV感染者和未感染者。这些DNA甲基化的核心特征被证实与HIV感染的两种典型病理症状--过早衰老和免疫调节异常有着重要的功能联系，揭示了HIV感染对宿主细胞DNA甲基化状态的潜在调控机制，为HIV感染和AIDS的发病机制提供了新的见解。
Many complex diseases or traits are the results of both genetic and environmental factors. The environmental factors affect the human body by modifying its epigenetics, which controls the activity of genomes without mutating it. Viral infection is one of the common environmental factors for complex diseases. For example, the human immunodeficiency virus (HIV) infection can cause acquired immune deficiency syndrome (AIDS), HBV, and HCV infections are associated with hepatocellular carcinoma, and human papillomavirus infection is a causal factor in cervical carcinoma. In this study, to investigate how HIV infection affects DNA methylation, we analyzed the blood DNA methylation data of 485 512 sites in 44 HIV- and 142 HIV + patients. Several advanced computational methods were applied to identify the core distinctive features that were different between the HIV patients and the healthy controls. These methods can be used for differentiating HIV-infected patients from uninfected ones. These core distinctive DNA methylation features were confirmed to be functionally connected to premature aging and abnormal immune regulation, two typical pathological symptoms of HIV infection, revealing the potential regulatory mechanisms of HIV infection on the DNA methylation status of the host cells and provided novel insights on the pathogenesis of HIV infection and AIDS.