Optical fiber sensors-based temperature distribution measurement in ex vivo radiofrequency ablation with submillimeter resolution
Optical fiber sensors-based temperature distribution measurement in ex vivo radiofrequency ablation with submillimeter resolution
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DOI：
10.1117/1.jbo.19.11.117004
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发表时间：
2014-11-01
影响因子：
3.5
通讯作者：
Lewis, Elfed
中科院分区：
文献类型：
--
作者：
Macchi, Edoardo Gino;Tosi, Daniele;Lewis, Elfed
射频热消融（RFTA）在生物组织中诱导具有陡峭的空间（高达6摄氏度/mm）和时间（高达1摄氏度/秒）梯度的高温场。RFTA应用于癌症护理，产生局部加热，对肿瘤细胞具有细胞毒性，并且能够治疗直径高达3至5 cm的肿瘤。先前已经用微型热电偶和光纤传感器进行了RFTA护理点处的温度分布的在线测量，其表现出尺寸、RFTA图案的改变、滞后和传感器密度差于1个传感器/cm的问题。在这项工作中，我们采用了分布式温度传感器（MEMS）与亚毫米空间分辨率的监测RFTA在猪肝组织。利用干涉仪对混沌瑞利后向散射图样进行了处理，得到了实时温度分布。建立了一个测量室，光纤沿沿着不同直径穿过组织。已经进行了几个实验，测量RFTA过程中温度的时空演变。目前的工作展示了RFTA中的温度监测具有前所未有的空间分辨率，并且可导出到体内测量;所获得的数据对于验证RFTA计算模型特别有用。(C)2014年，美国光电仪器工程师学会（SPIE）
Radiofrequency thermal ablation (RFTA) induces a high-temperature field in a biological tissue having steep spatial (up to 6 degrees C/mm) and temporal (up to 1 degrees C/s) gradients. Applied in cancer care, RFTA produces a localized heating, cytotoxic for tumor cells, and is able to treat tumors with sizes up to 3 to 5 cm in diameter. The online measurement of temperature distribution at the RFTA point of care has been previously carried out with miniature thermocouples and optical fiber sensors, which exhibit problems of size, alteration of RFTA pattern, hysteresis, and sensor density worse than 1 sensor/cm. In this work, we apply a distributed temperature sensor (DTS) with a submillimeter spatial resolution for the monitoring of RFTA in porcine liver tissue. The DTS demodulates the chaotic Rayleigh backscattering pattern with an interferometric setup to obtain the real-time temperature distribution. A measurement chamber has been set up with the fiber crossing the tissue along different diameters. Several experiments have been carried out measuring the space-time evolution of temperature during RFTA. The present work showcases the temperature monitoring in RFTA with an unprecedented spatial resolution and is exportable to in vivo measurement; the acquired data can be particularly useful for the validation of RFTA computational models. (C) 2014 Society of Photo-Optical Instrumentation Engineers (SPIE)