SULFOXIDE-METAL EXCHANGE FOR THE SYNTHESIS OF THE 2′-TRIBUTYLSTANNYL DERIVATIVE OF 2′,3′-DIDEHYDRO-2′,3′-DIDEOXYURIDINE (d4U): A GENERAL ENTRY TO 2′-CARBON-SUBSTITUTED ANALOGUES OF d4U
SULFOXIDE-METAL EXCHANGE FOR THE SYNTHESIS OF THE 2′-TRIBUTYLSTANNYL DERIVATIVE OF 2′,3′-DIDEHYDRO-2′,3′-DIDEOXYURIDINE (d4U): A GENERAL ENTRY TO 2′-CARBON-SUBSTITUTED ANALOGUES OF d4U
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硫氧化物-金属交换合成 2,3-二氢-2,3-二脱氧尿苷 (d4U) 的 2-三丁基甲锡烷基衍生物：2-碳取代的 d4U 类似物的一般条目
DOI：
10.1081/ncn-120006826
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
T. Satoh
中科院分区：
文献类型：
--
作者：
H. Kumamoto;Sayoko Onuma;Kumiko Tsuchiya;Yuko Egusa;Hiromichi Tanaka;T. Satoh
ABSTRACT Methods are described for the synthesis of the 2′-tributylstannyl derivative of 2′,3′-didehydro-2′, 3′-dideoxyuridine (d4U). Two approaches were investigated: radical-mediated desulfonylative stannylation of the 2′-benzenesulfonyl derivative of d4U and sulfoxide-metal exchange reaction of the 2′-benzenesulfinyl derivative. The latter approach was found to give the desired 2′-stannyl derivative in good yield. It was also shown that manipulations of the stannyl group allowed the introduction of a variety of carbon-substituents to the 2′-position by applying the Stille reaction. The whole reaction sequence has opened up a highly general entry to 2′-carbon-substituted analogues of d4U.
影响因子：
2.1
作者：
T. Satoh;Koji Takano;H. Ota;H. Someya;K. Matsuda;M. Koyama
通讯作者：
T. Satoh;Koji Takano;H. Ota;H. Someya;K. Matsuda;M. Koyama