Cytotoxic potential of decidual NK cells and CD8+ T cells awakened by infections.
Cytotoxic potential of decidual NK cells and CD8+ T cells awakened by infections.
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DOI：
10.1016/j.jri.2016.08.001
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发表时间：
2017-02
影响因子：
3.4
通讯作者：
Tilburgs T
中科院分区：
文献类型：
--
作者：
Crespo ÂC;van der Zwan A;Ramalho-Santos J;Strominger JL;Tilburgs T
为了建立一个健康的妊娠，母体免疫系统必须耐受胎儿同种异体抗原，但仍能对感染作出反应。蜕膜NK细胞（dNK）促进胎儿绒毛外滋养层细胞（EVT）迁移和胎盘生长的能力以及EVT促进免疫耐受的能力是高度关注和广泛研究的主题。然而，dNK和蜕膜CD 8 + T细胞（CD 8 + dT）如何提供对胎盘感染的免疫力以及调节其细胞溶解功能的机制的问题迄今为止在很大程度上被忽视。胎儿EVT是胎盘中最具侵袭性的细胞，并在该母胎界面直接与母体蜕膜免疫细胞相互作用。除了与免疫耐受相关的非多态性HLA-E和HLA-G分子的表达外，EVT还表达高度多态性的HLA-C分子，其可作为母体dNK和CD 8 + dT应答的靶标。EVT表达的HLA-C具有双重作用，作为需要建立免疫耐受的主要分子，以及作为在EVT感染时可以呈递病原体衍生肽并提供保护性免疫的唯一分子。这篇综述的重点是解决调节细胞毒性的dNK和CD 8 + dT，这是必不可少的母胎免疫耐受，以及最近的证据表明，这两种细胞类型可以提供免疫感染的母胎界面。一个特别强调的作用是由EVT和它的能力，引起dNK和CD 8 + dT反应的HLA-C表达。
To establish a healthy pregnancy the maternal immune system must tolerate fetal allo-antigens, yet remain competent to respond to infections. The ability of decidual NK cells (dNK) to promote migration of fetal extravillous trophoblasts (EVT) and placental growth as well as the capacity of EVT to promote immune tolerance are topics of high interest and extensive research. However, the problem of how dNK and decidual CD8+ T cells (CD8+ dT) provide immunity to infections of the placenta and the mechanisms that regulate their cytolytic function has thus far largely been ignored. Fetal EVT are the most invasive cells of the placenta and directly interact with maternal decidual immune cells at this maternal-fetal interface. Besides the expression of non-polymorphic HLA-E and HLA-G molecules that are associated with immune tolerance, EVT also express highly polymorphic HLA-C molecules that can serve as targets for maternal dNK and CD8+ dT responses. HLA-C expression by EVT has a dual role as the main molecule to which immune tolerance needs to be established and as the only molecule that can present pathogen-derived peptides and provide protective immunity when EVT are infected. The focus of this review is to address the regulation of cytotoxicity of dNK and CD8+ dT, which is essential for maternal-fetal immune tolerance as well as recent evidence that both cell types can provide immunity to infections at the maternal-fetal interface. A particular emphasis is given to the role of HLA-C expressed by EVT and its capacity to elicit dNK and CD8+ dT responses.