Biomarkers of mild traumatic brain injury in cerebrospinal fluid and blood.
Biomarkers of mild traumatic brain injury in cerebrospinal fluid and blood.
复制标题
脑脊液和血液中轻度创伤性脑损伤的生物标志物。
DOI：
10.1038/nrneurol.2013.9
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发表时间：
2013-04
期刊：
影响因子：
--
通讯作者：
Blennow K
中科院分区：
文献类型：
--
作者：
Zetterberg H;Smith DH;Blennow K
轻度创伤性脑损伤（TBI），定义为头部创伤导致短暂的意识丧失和/或精神状态改变，通常是良性的，但偶尔会导致持续性，有时是进行性症状。脑损伤和/或个体脆弱性的阈值是否可能导致这些长期后果的发展尚不清楚。此外，缺乏可靠的诊断方法来确定头部受到的打击是否影响了大脑（以及以何种方式）。在这篇综述中，我们讨论了可以在体液中检测到的CNS中不同结构和细胞类型损伤的潜在生物标志物。我们提出的论点支持需要进一步开发和验证这些生物标志物，并将其用于评估头部创伤患者的大脑可能受到影响。具体来说，我们专注于需要这样的生物标志物在管理运动相关的脑震荡，最常见的原因轻度TBI的年轻人，以防止长期的神经系统后遗症由于脑震荡或亚脑震荡打击头部。
Mild traumatic brain injury (TBI), which is defined as a head trauma resulting in a brief loss of consciousness and/or alteration of mental state, is usually benign, but occasionally causes persistent and sometimes progressive symptoms. Whether a threshold for the amount of brain injury and/or individual vulnerability might contribute to the development of these long-term consequences is unknown. Furthermore, reliable diagnostic methods that can establish whether a blow to the head has affected the brain (and in what way) are lacking. In this Review, we discuss potential biomarkers of injury to different structures and cell types in the CNS that can be detected in body fluids. We present arguments in support of the need for further development and validation of such biomarkers, and for their use in assessing patients with head trauma in whom the brain might have been affected. Specifically, we focus on the need for such biomarkers in the management of sports-related concussion, the most common cause of mild TBI in young individuals, to prevent long-term neurological sequelae due to concussive or subconcussive blows to the head.