Npas4: Linking Neuronal Activity to Memory.
Npas4: Linking Neuronal Activity to Memory.
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DOI：
10.1016/j.tins.2016.02.003
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发表时间：
2016-04
影响因子：
15.9
通讯作者：
Lin Y
中科院分区：
文献类型：
--
作者：
Sun X;Lin Y
立即早期基因（IEGs）在感觉和行为体验后迅速激活，被认为是将经验转化为长期记忆的关键。神经元PAS结构域蛋白4（Npas4）是最近发现的一种IEG，它具有以下几个特点，使其可能成为神经元活动和记忆之间特别重要的分子联系：它是诱导最快的IEG之一，仅在神经元中表达，并且被神经元活动选择性地诱导。通过在不同的神经元群体中协调不同的活性依赖性基因程序，Npas4影响兴奋性和抑制性神经元中的突触连接、神经回路可塑性和记忆形成。它也可能通过负反馈和精神疾病参与回路稳态。我们总结了这些发现，并讨论了它们的影响。
Immediate early genes (IEGs) are rapidly activated after sensory and behavioral experience and are believed to be critical for converting experience into long-term memory. Neuronal PAS domain protein 4 (Npas4), a recently discovered IEG, has several characteristics that make it likely to be a particularly important molecular link between neuronal activity and memory: it is among the most rapidly induced IEGs, is expressed only in neurons, and is selectively induced by neuronal activity. By orchestrating distinct activity-dependent gene programs in different neuronal populations, Npas4 affects synaptic connections in excitatory and inhibitory neurons, neural circuit plasticity and memory formation. It may also be involved in circuit homeostasis through negative feedback and psychiatric disorders. We summarize these findings and discusses their implications.