A circadian rhythm-gated subcortical pathway for nighttime-light-induced depressive-like behaviors in mice
A circadian rhythm-gated subcortical pathway for nighttime-light-induced depressive-like behaviors in mice
复制标题
夜间光诱导小鼠抑郁样行为的昼夜节律门控皮层下通路
DOI：
10.1038/s41593-020-0640-8
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发表时间：
2020-06-01
影响因子：
25
通讯作者：
Xue, Tian
中科院分区：
文献类型：
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作者：
An, Kai;Zhao, Huan;Xue, Tian
除了产生视觉，光还调节各种生理功能，包括情绪。虽然在白天应用光疗已知具有抗抑郁的特性，但据报道，晚上过度暴露在光线下与抑郁症状有关。这种昼夜光效应差异背后的神经机制尚不清楚。在小鼠的夜间光照(LAN)实验中，我们证明了LAN在不干扰昼夜节律的情况下诱导了类似抑郁的行为。这种作用是通过从视网膜黑素表达的神经节细胞到缰核背侧核(DpHb)再到伏核(Nac)的神经通路来实现的。重要的是，dphb受到昼夜节律的控制，夜间比白天更容易兴奋。这表明ipRGC->；dpHb->；NAC通路在夜间优先传导光信号，从而介导了局域网络诱导的抑郁样行为。当考虑到工业世界中普遍存在的夜间照明对心理健康的影响时，这些发现可能是相关的。在小鼠身上发现了一种新的大脑通路，在昼夜节律门控下将光信号从视网膜传递到与情绪相关的皮质下核团，从而调节由异常夜间光线暴露引起的抑郁样行为。
Besides generating vision, light modulates various physiological functions, including mood. While light therapy applied in the daytime is known to have anti-depressive properties, excessive light exposure at night has been reportedly associated with depressive symptoms. The neural mechanisms underlying this day-night difference in the effects of light are unknown. Using a light-at-night (LAN) paradigm in mice, we showed that LAN induced depressive-like behaviors without disturbing the circadian rhythm. This effect was mediated by a neural pathway from retinal melanopsin-expressing ganglion cells to the dorsal perihabenular nucleus (dpHb) to the nucleus accumbens (NAc). Importantly, the dpHb was gated by the circadian rhythm, being more excitable at night than during the day. This indicates that the ipRGC -> dpHb -> NAc pathway preferentially conducts light signals at night, thereby mediating LAN-induced depressive-like behaviors. These findings may be relevant when considering the mental health effects of the prevalent nighttime illumination in the industrial world.An et al. discovered a new brain pathway in mice that conveys light signals from the retina to mood-relevant subcortical nuclei under circadian gating and thereby mediates depressive-like behaviors induced by abnormal nighttime light exposure.