Cu(I)-Catalyzed Tandem Reaction of Carbene Coupling and Horner-Wadsworth-Emmons Type Olefination: Access toward Enynes
Cu(I)-Catalyzed Tandem Reaction of Carbene Coupling and Horner-Wadsworth-Emmons Type Olefination: Access toward Enynes
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Cu(I) 催化卡宾偶联和 Horner-Wadsworth-Emmons 型烯化的串联反应：获得烯炔
DOI：
10.1021/acs.orglett.6b00631
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发表时间：
2016
期刊：
影响因子：
5.2
通讯作者：
Wang Jianbo
中科院分区：
文献类型：
--
作者：
Zhou Yujing;Ye Fei;Zhou Qi;Zhang Yan;Wang Jianbo
基于Cu(I)催化α-重氮膦酸盐与炔烃的交叉偶联反应和随后的Horner-Wadsworth-Emmons （HWE）型反应，成功地合成了1,3-炔的新策略。该方法直接获得共轭炔，效率高，具有良好的立体选择性和良好的官能团相容性。铜(I)碳烯迁移插入在这一转变中起着至关重要的作用。
A novel strategy to synthesize 1,3-enynes has been successfully developed based on Cu(I)-catalyzed cross-coupling of α-diazo phosphonates and alkynes with a subsequent Horner–Wadsworth–Emmons (HWE) type reaction. This method provides straightforward access to conjugated enynes with high efficiency, good stereoselectivity and excellent functional group compatibility. Copper(I) carbene migratory insertion plays a crucial role in this transformation.