Counting single cells and computing their heterogeneity: from phenotypic frequencies to mean value of a quantitative biomarker.
Counting single cells and computing their heterogeneity: from phenotypic frequencies to mean value of a quantitative biomarker.
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DOI:
10.1007/s40484-020-0196-3
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发表时间:
2020-07-13
期刊:
影响因子:
--
通讯作者:
Cheng YC
中科院分区:
文献类型:
--
作者:
Qian H;Cheng YC
This tutorial presents a mathematical theory that relates the probability of sample frequencies, of M phenotypes in an isogenic population of N cells, to the probability distribution of the sample mean of a quantitative biomarker, when the N is very large. An analogue to the statistical mechanics of canonical ensemble is discussed.
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