Asymmetric ring-opening of cyclopropyl ketones with β-naphthols catalyzed by a chiral N,N′-dioxide–scandium(III) complex
Asymmetric ring-opening of cyclopropyl ketones with β-naphthols catalyzed by a chiral N,N′-dioxide–scandium(III) complex
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DOI：
10.1039/c8qo00016f
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发表时间：
2018-04
影响因子：
5.4
通讯作者：
Yong Xia;Fenzhen Chang;Lili Lin;Yali Xu;Xiaohua Liu;Xiaoming Feng
中科院分区：
文献类型：
--
作者：
Yong Xia;Fenzhen Chang;Lili Lin;Yali Xu;Xiaohua Liu;Xiaoming Feng
A catalytic asymmetric ring-opening reaction of cyclopropyl ketones with β-naphthols has been accomplished. In the presence of a chiral N,N′-dioxide/scandium(III) complex, a series of aromatic or vinyl substituted cyclopropyl ketones reacted with 2-naphthols, providing efficient access to chiral β-naphthol derivatives in good yields (up to 99%) with good enantioselectivities (up to 97% ee). Notably, using the mixture of 2-naphthol substrates did not affect the efficiency of this catalytic system.
