The role of membrane contact sites at the bacteria-host interface
The role of membrane contact sites at the bacteria-host interface
复制标题
细菌-宿主界面上膜接触位点的作用
DOI：
10.1080/1040841x.2021.1961678
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发表时间：
--
影响因子：
6.5
通讯作者：
Yang Aimin
中科院分区：
文献类型：
--
作者：
Jiang Chen;Huang Xue;Yao Jia;Yu Lihua;Wei Fujing;Yang Aimin
膜接触点（MCSs）是指异源膜之间的邻近区域。越来越多的证据表明，MCSs参与重要的细胞功能，如细胞物质转移、细胞器生物发生和细胞生长。重要的是，研究细菌-宿主界面上的MCSs是一个新兴的热门研究课题。细胞内细菌病原体已经进化出多种迷人的策略，通过向受感染的宿主细胞注射效应器来干扰mcs。含有细菌的液泡与宿主细胞器建立直接的物理接触，确保液泡膜的完整性和宿主细胞器的能量供应，并保护液泡免受宿主内吞途径和溶酶体降解的影响。越来越多来自各种细菌病原体的细菌效应物劫持宿主MCSs的成分，形成液泡-细胞器MCSs进行物质交换。mcs相关事件已被确定为微生物发病的新机制，极大地改善了宿主细胞内细菌的生存和复制。在本文中，我们将讨论细菌-宿主界面MCSs的最新进展，重点讨论由细菌效应物介导的MCSs在微生物发病机制中的作用。
Abstract Membrane contact sites (MCSs) refer to the areas of close proximity between heterologous membranes. A growing body of evidence indicates that MCSs are involved in important cellular functions, such as cellular material transfer, organelle biogenesis, and cell growth. Importantly, the study of MCSs at the bacteria-host interface is an emerging popular research topic. Intracellular bacterial pathogens have evolved a variety of fascinating strategies to interfere with MCSs by injecting effectors into infected host cells. Bacteria-containing vacuoles establish direct physical contact with organelles within the host, ensuring vacuolar membrane integrity and energy supply from host organelles and protecting the vacuoles from the host endocytic pathway and lysosomal degradation. An increasing number of bacterial effectors from various bacterial pathogens hijack components of host MCSs to form the vacuole-organelle MCSs for material exchange. MCS-related events have been identified as new mechanisms of microbial pathogenesis to greatly improve bacterial survival and replication within host cells. In this review, we will discuss the recent advances in MCSs at the bacteria-host interface, focussing on the roles of MCSs mediated by bacterial effectors in microbial pathogenesis.