Effects of Endogenous Histamine on Seizure Development of Pentylenetetrazole-Induced Kindling in Rats
Effects of Endogenous Histamine on Seizure Development of Pentylenetetrazole-Induced Kindling in Rats
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DOI：
10.1159/000071263
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发表时间：
2003-08
期刊：
影响因子：
3.1
通讯作者：
Li-san Zhang;Zhong Chen;Yu-wen Huang;Weiwei Hu;E. Wei;K. Yanai
中科院分区：
文献类型：
--
作者：
Li-san Zhang;Zhong Chen;Yu-wen Huang;Weiwei Hu;E. Wei;K. Yanai
This study was performed to investigate whether or not endogenous histamine can protect seizure development of pentylenetetrazole (PTZ)-induced kindling in rats. An intracerebroventricular (i.c.v.) injection with clobenpropit (5 and 10 µg), a representative H3-antagonist, significantly prolonged the onset of kindling and inhibited the seizure stages in a dose-dependent manner. Its action was significantly reversed by both immepip (2 µg, i.c.v.), an H3-agonist, and α-fluoromethylhistidine (α-FMH, 10 µg, i.c.v.), a selective histidine decarboxylase inhibitor. α-FMH (20 µg, i.c.v.) and pyrilamine (1 and 5 mg/kg i.p.), a classical H1-antagonist, markedly augmented the severity of seizure development of PTZ-induced kindling. Therefore, these results indicate that brain endogenous histamine plays a certain protective role on seizure development of PTZ-induced kindling in rats, and that its protective roles are mediated by H1-receptors.
